Dermonecrotic toxin

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Dermonecrotic toxin
other names
  • Heat-labile toxin
Mass / length primary structure 1,464 amino acids , 160,698 Da
Identifier
External IDs

Dermonecrotic toxin (DT) is a protein from Bordetella sp. and a microbial exotoxin .

properties

The dermonecrotic toxin is produced by Bordetella bronchiseptica and Bordetella parapertussis . It is an AB toxin and belongs to the group of cytotoxic necrotising factors , as does CNF1 . DT is a virulence factor in infections with Bordetella sp. in man. DT leads to the formation of actin stress fibers and focal adhesion by deamination or amination of the amino acid glutamine at position 63 on the GTPase Rho , whereby Rho becomes constitutively active. Uptake into cells occurs through clathrin-mediated endocytosis . DT is instrumental in the development of atrophic rhinitis in pigs, along with the Pasteurella multocida toxin from Pasteurella multocida .

Web links

Individual evidence

  1. ↑ M. Lemonnier, L. Landraud, E. Lemichez: Rho GTPase-activating bacterial toxins: from bacterial virulence regulation to eukaryotic cell biology. In: FEMS microbiology reviews. Volume 31, Number 5, September 2007, pp. 515-534, doi : 10.1111 / j.1574-6976.2007.00078.x , PMID 17680807 .
  2. ↑ T. Matsuzawa, T. Kashimoto, J. Katahira, Y. Horiguchi: Identification of a receptor-binding domain of Bordetella dermonecrotic toxin. In: Infection and Immunity. Volume 70, Number 7, July 2002, pp. 3427-3432, PMID 12065482 , PMC 128056 (free full text).
  3. ↑ A. Fukui, Y. Horiguchi: Bordetella dermonecrotic toxin exerting toxicity through activation of the small GTPase Rho. In: Journal of biochemistry. Volume 136, Number 4, October 2004, pp. 415-419, doi : 10.1093 / jb / mvh155 , PMID 15625308 .
  4. ^ Y. Horiguchi: Swine atrophic rhinitis caused by pasteurella multocida toxin and bordetella dermonecrotic toxin. In: Current topics in microbiology and immunology. Volume 361, 2012, pp. 113-129, doi : 10.1007 / 82_2012_206 , PMID 22411430 .