Pasteurella multocida toxin
| Pasteurella multocida toxin | ||
|---|---|---|
| other names |
Mitogenic toxin, PMT strain NCTC 12178, Dermonecrotic toxin |
|
| Mass / length primary structure | 1,285 amino acids , 146,383 Da | |
| Identifier | ||
| External IDs | ||
Pasteurella multocida toxin (PMT, Dermonecrotic Toxin ) is a protein from Pasteurella multocida and a microbial exotoxin .
properties
PMT is a necrotizing toxin that affects the skin and bones . It is also a mitogen and promotes cell division due to the deamination of heterotrimeric G proteins on the α subunit in types G (q), G (i) and G (12/13). PMT is instrumental in the development of atrophic rhinitis in pigs, along with the dermonecrotic toxin from Bordetella .
Web links
Individual evidence
- ^ BA Wilson, M. Ho: Pasteurella multocida toxin interaction with host cells: entry and cellular effects. In: Current topics in microbiology and immunology. Volume 361, 2012, pp. 93–111, doi : 10.1007 / 82_2012_219 , PMID 22552700 , PMC 4408768 (free full text).
- ^ Y. Horiguchi: Swine atrophic rhinitis caused by pasteurella multocida toxin and bordetella dermonecrotic toxin. In: Current topics in microbiology and immunology. Volume 361, 2012, pp. 113-129, doi : 10.1007 / 82_2012_206 , PMID 22411430 .