Dichelobacter nodosus

Dichelobacter nodosus
Systematics
Domain :	Bacteria (bacteria)
Class :	Gammaproteobacteria
Order :	Cardiobacteriales
Family :	Cardiobacteriaceae
Genre :	Dichelobacter
Type :	Dichelobacter nodosus
Scientific name
	Dichelobacter nodosus
	(Beveridge 1941) (Mraz 1963) Dewhirst et al. 1990

Dichelobacter nodosus is a gram-negative , obligately anaerobic rod-shaped bacterium. It triggers of foot rot , a purulent disease of the claw horn especially in sheep . The basionyma is Bacteroides nodosus (Beveridge 1941) Mraz 1963 , in 1990 it was transferredto the new genus Dichelobacteron the basis of the 16S rRNA sequence.

In a moist environment, the pathogen can survive outside the claw horn for up to 14 days. The cultivation of the pathogen is very complex and only rarely succeeds. Therefore, detection by the polymerase chain reaction is more reliable. D. nodosus forms various proteases that enable the claw horn to dissolve. The proteases encoded by the AprV2, AprV5 and BprV genes play a role here as virulence factors , with strains with the AprV2 enzyme ( acidic protease isoenzyme 2 ) having the strongest disease-causing effect. The proteases are initially produced by the bacterium as inactive precursors, which are activated by splitting off the N-terminal pre-pro region and the C-terminal domain .

Individual evidence

↑ FE Dewhirst, BJ Paster, S. La Fontaine, JI Rood: Transfer of Kingella indologenes (Snell and Lapage 1976) to the genus Suttonella gen. Nov. as Suttonella indologenes comb. nov .; transfer of Bacteroides nodosus (Beveridge 1941) to the genus Dichelobacter gen. nov. as Dichelobacter nodosus comb. nov .; and assignment of the genera Cardiobacterium, Dichelobacter, and Suttonella to Cardiobacteriaceae fam. nov. in the gamma division of Proteobacteria on the basis of 16S rRNA sequence comparisons. In: International journal of systematic bacteriology. Volume 40, Number 4, October 1990, pp. 426-433, doi : 10.1099 / 00207713-40-4-426 , PMID 2275858 .
↑ SE Cederlöf et al .: An evaluation of the ability of Dichelobacter nodosus to survive in soil. In: Acta Vet Scand , Volume 55, 2013, p. 4.
↑ Deborah Greber: Mold limp with sheep - new approaches to remediation. In: veterinär spiegel , volume 27, 2017, issue 3, pp. 114–118, DOI: 10.1055 / s-0043-116456 .
↑ RM Kennan et al .: The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates. In: PLoS pathogens. Volume 6, number 11, November 2010, p. E1001210, doi : 10.1371 / journal.ppat.1001210 , PMID 21124876 , PMC 2991261 (free full text).

[1] FE Dewhirst, BJ Paster, S. La Fontaine, JI Rood: Transfer of Kingella indologenes (Snell and Lapage 1976) to the genus Suttonella gen. Nov. as Suttonella indologenes comb. nov .; transfer of Bacteroides nodosus (Beveridge 1941) to the genus Dichelobacter gen. nov. as Dichelobacter nodosus comb. nov .; and assignment of the genera Cardiobacterium, Dichelobacter, and Suttonella to Cardiobacteriaceae fam. nov. in the gamma division of Proteobacteria on the basis of 16S rRNA sequence comparisons. In: International journal of systematic bacteriology. Volume 40, Number 4, October 1990, pp. 426-433, doi : 10.1099 / 00207713-40-4-426 , PMID 2275858 .

[2] SE Cederlöf et al .: An evaluation of the ability of Dichelobacter nodosus to survive in soil. In: Acta Vet Scand , Volume 55, 2013, p. 4.

[3] Deborah Greber: Mold limp with sheep - new approaches to remediation. In: veterinär spiegel , volume 27, 2017, issue 3, pp. 114–118, DOI: 10.1055 / s-0043-116456 .

[4] RM Kennan et al .: The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates. In: PLoS pathogens. Volume 6, number 11, November 2010, p. E1001210, doi : 10.1371 / journal.ppat.1001210 , PMID 21124876 , PMC 2991261 (free full text).