Didier Stainier

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Didier Stainier, 2012

Didier YR Stainier (born October 31, 1963 in Liège ) is a Belgian-American biologist and developmental geneticist .

Life

Didier Stainier studied biology at the United World College of the Atlantic in Wales , the University of Liege in Belgium and the Brandeis University in Waltham in the US state of Massachusetts . In 1990 he graduated as a Ph.D. in biochemistry and molecular biology from Harvard University . He was then a postdoctoral fellow at the Massachusetts General Hospital in Boston , became Assistant Professor at the University of California, San Francisco (UCSF) in 1995, Associate Professor in 2000 and Professor in 2003. Since 2012 he has been director at the Max Planck Institute for Heart and Lung Research in Bad Nauheim and director of the "Development Genetics" department. At the same time, he has been a "Scientific Member" of the Max Planck Society since 2012.

research

Stainier deals with issues of organogenesis including cell differentiation , tissue morphogenesis , organ homeostasis and function as well as organ regeneration. He mainly uses zebrafish and mice as model organisms .

Selected publications

  • S. Reischauer, O. Stone, A. Villasenor, N. Chi, SW Jin, M. Martin, MT Lee, N. Fukuda, M. Marass, A. Witty, I. Fiddes, T. Kuo, WS Chung, S. Salek, R. Lerrigo, J. Alsiö, S. Luo, D. Tworus, SM Augustine, S. Mucenieks, B. Nystedt, AJ Giraldez, GP Schroth, O. Andersson, DY Stainier: Cloche is a bHLH-PAS transcription factor that drives hemato-vascular specification. In: Nature . 535, 2016, pp. 294-298.
  • A. Rossi, Z. Kontarakis, C. Gerri, H. Nolte, S. Hölper, M. Krüger, DY Stainier: Genetic compensation induced by deleterious mutations but not gene knockdowns. In: Nature. 524, 2015, pp. 230-233.
  • O. Andersson, BA Adams, D. Yoo, GC Ellis, P. Gut, RM Anderson, MS German, DYR Stainier: Adenosine signaling promotes regeneration of pancreatic β-cells in vivo. In: Cell Metabolism . 15, 2012, pp. 885-894.
  • AB Arrenberg, DYR Stainier, H. Baier, J. Huisken: Optogenetic control of cardiac function. In: Science . 330, 2010, pp. 971-974.
  • SP Herbert, J. Huisken, TN Kim, ME Feldman, BT Houseman, RA Wang, KM Shokat, DYR Stainier: Arterial / Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation. In: Science. 326, 2009, pp. 294-298.
  • N. Osborne, K. Brand-Arzamendi, EA Ober, SW Jin, H. Verkade, NG Holtzman, D. Yelon, DYR Stainier: The Spinster homologue, Two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. In: Current Biology . 18, 2008, pp. 1882-1888.
  • M. Bagnat, ID Cheung, KE Mostov, DYR Stainier: Genetic control of single lumen formation in the zebrafish gut. Nature Cell Biology . 9, 2007, pp. 954-960.
  • KM Vogeli, S.-W. Jin, GR Martin, DYR Stainier: A common progenitor for hematopoietic and endothelial lineages in the zebrafish gastrula. In: Nature. 443, 2006, pp. 337-339.
  • EA Ober, H. Verkade, HA Field, DYR Stainier: Mesodermal Wnt2b signaling positively regulates liver specification. In: Nature. 442, 2006, pp. 688-691.
  • S. Horne-Badovinac, M. Rebagliati, DYR Stainier: A cellular framework for gut looping morphogenesis in zebrafish. In: Science. 302, 2003, pp. 662-665.
  • EC Walsh, DYR Stainier: UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish. In: Science. 293, 2001, pp. 1670-1673.
  • E. Kupperman, S. An, N. Osborne, S. Waldron, DYR Stainier: A sphingosine 1-phosphate receptor regulates cell migration during vertebrate heart development. In: Nature. 406, 2000, pp. 192-195.
  • J. Alexander, DYR Stainier: A molecular pathway leading to endoderm formation in zebrafish. In: Current Biology. 9, 1999, pp. 1147-1157.

honors and awards

literature

Web links


personal data
SURNAME Stainier, Didier
ALTERNATIVE NAMES Stainier, Didier YR
BRIEF DESCRIPTION Belgian biologist and developmental geneticist
DATE OF BIRTH October 31, 1963
PLACE OF BIRTH Liege