Dimidium bromide

Structural formula
General
Surname	Dimidium bromide
other names	3,8-diamino-5-methyl-6-phenyl-phenanthridinium bromide ( IUPAC ) Trypadin
Molecular formula	C 20 H 18 BrN 3
Brief description	red-brown odorless solid
External identifiers / databases
CAS number 518-67-2 (anhydrous) 37889-60-4 (monohydrate) PubChem 68207 Wikidata Q1225774
properties
Molar mass	380.28 g mol −1
Physical state	firmly
Melting point	243-248 ° C
solubility	soluble in water (at 20 ° C)
safety instructions
GHS labeling of hazardous substances Caution H and P phrases H: 315-319-335 P: 261-305 + 351 + 338
Toxicological data	61 mg kg −1 ( LD 50 ,  mouse ,  sc ) 7.3 mg kg −1 ( LD 50 ,  mouse ,  iv )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Dimidium bromide is a polycyclic organic compound from the group of phenanthridine dyes . The red, odorless substance is sparingly soluble in water, better in organic solvents such as chloroform, dichloromethane and methanol. The homologous ethyl derivative is ethidium bromide .

use

Dimidium bromide is used together with disulfine blue VN 150 as a mixed indicator for an Epton titration . It is also used as a detection reagent for nucleic acids .

Individual evidence

1. ↑ ^{a b c} data sheet dimidium bromide (PDF) from Merck , accessed on December 5, 2016.
2. ↑ ^{a b c} Datasheet Dimidium bromide from Sigma-Aldrich , accessed on December 5, 2016 ( PDF ).
3. ↑ ^{a b} data sheet  ( page no longer available , search in web archives ) at caledonlabs.com (PDF; 53 kB).
4. ↑ G. Dougherty: A comparison of the base-pair specificities of three phenanthridine drugs using solution spectroscopy , in: Int. J. Biochem. 1982 , 14 (6) , pp. 493-504; PMID 7106349 .