Diminazen

Structural formula
General
Non-proprietary name	Diminazen
other names	4,4 '- (Triazene-1,3-diyl) dibenzen carbimidamide
Molecular formula	C 14 H 15 N 7
External identifiers / databases
EC number	208-644-6
ECHA InfoCard	100.007.860
PubChem	2354
ChemSpider	2264
DrugBank	DB03608
Wikidata	Q410958
Drug information
ATC code	Q P51AF01
Drug class	Antiprotozoic
Mechanism of action	unknown
properties
Molar mass	281.32 g · mol -1
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Diminazen is a drug from the group of aromatic di- amidines . Diminazen is used in veterinary medicine as a diaceturate salt ( N -acetylglycinate) intramuscularly, subcutaneously or cutaneously against pathogenic protozoa such as Babesia , Trypanosoma , Leishmania and Cytauxzoon and against some bacteria ( Brucella and streptococci ). The exact mechanism of action is not yet known exactly diminazene probably inhibits DNA - replication .

Since the active ingredient is not listed in any annex of Regulation (EEC) No. 2377/90 on maximum levels for veterinary drug residues in food , the use of Diminazen in food-producing animals is prohibited in the European Union.

Side effects

Diminazen can cause severe, sometimes fatal, damage to the liver, kidneys and brain. Acute side effects are vomiting, diarrhea, and low blood pressure.

Camels in particular are very sensitive to Diminazen, and fatal incidents can occur even at therapeutic doses.

Trade names

Azidine, Berenil, Ganasag, Pirocide

literature

Peregrine, AS and Mamman, M. (1993): Pharmacology of diminazene: a review. In: Acta Trop. 54 (3-4); 185-203. PMID 7902657 .

Web links

Entry to diminazene at Vetpharm

Individual evidence

↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
^ Lut, Lynen: Local application of diminazene aceturate: An effective treatment for cutaneous leishmaniasis? In: researchgate.net. ResearchGate, April 1, 1992, accessed April 9, 2020 .

[NV-1] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[2] Lut, Lynen: Local application of diminazene aceturate: An effective treatment for cutaneous leishmaniasis? In: researchgate.net. ResearchGate, April 1, 1992, accessed April 9, 2020 .