Donald pee
Donald Paul Pinkel (born September 7, 1926 in Buffalo ) is an American pediatrician and pioneer of clinical leukemia research, whose specialty is pediatric hematology and oncology .
He has received multiple awards for research into the cure for childhood cancers, including leukemia .
In 1962 Pinkel became the first director of the newly established St. Jude Children's Research Hospital in Memphis , Tennessee , whose medical direction he held until 1973. He has published several books, articles in specialist books and journals.
Director of the St. Jude Children's Research Hospital
During his time as director and CEO at St. Jude Children's Research Hospital from 1962 to 1973, the focus of his work was on research into acute lymphoblastic leukemia (ALL), the most common childhood cancer. Pinkel and his colleagues identified four main obstacles to healing: existing or acquired drug resistance ( chemoresistance ), disease relapse ( relapse ) in the central nervous system (CNS) due to insufficient CNS effective levels of chemotherapeutic agents , treatment- related immunosuppression with life-threatening infections, epithelial damage (inflammation of the mucous membranes, "Mucositis"), and the so-called therapeutic pessimism of doctors in treating the disease. The latter led to a negative attitude of many paediatricians according to the motto "the children will die of the disease, you don't have to torture them with intensive treatments (chemotherapy, radiation therapy)". For the first time, Pinkel et al. Systematically used prophylactic irradiation of the central nervous system and also the intrathecal administration of cytostatic drugs to combat CNS relapses . To prevent relapses, the intensity of the chemotherapy was increased to a previously unknown level, while accepting the corresponding side effects.
Pinkel and his colleagues at St. Jude conducted the first consistent therapy studies and developed a treatment program that was geared towards the complete cure of ALL. This "Total Therapy" was based on all clinical research and laboratory results and experience available at the time. The therapy included a combination of various cytostatic drugs with a CNS prophylaxis ( intrathecal chemotherapy or CNS - irradiation ) to prevent the CNS relapse.
This therapy increased the cure rate in children with ALL from less than 10% in the 1960s to around 50% in the 1970s. Thanks to better measures to prevent infections and constant further development of drugs and therapy, the recovery rate among children in industrialized countries is now 75–85%.
Awards
Pinkel received the Albert Lasker Award for Clinical Medical Research in 1972, the Kettering Prize in 1986 for his cancer research and the Pollin Prize for Pediatric Research in 2003 for his pediatric research .
The American Cancer Society gave him the Annual Award for Clinical Research and the Leukemia & Lymphoma Society of America the Return of the Child award . In Germany he was awarded the Johann Georg Zimmermann Medal in 1979 and in the UK he was awarded the Leukemia Society Annual Lectureship and the Windermere Lectureship of the Royal College of Pediatrics and Child Health .
In 2017 the newly built research tower of the St. Jude Children's Research Hospital was named after him.
Individual evidence
- ^ Who's who in the South and Southwest . Marquis Who's Who, 2004, ISBN 978-0-8379-0834-2 ( limited preview in Google Book Search).
- ↑ a b c d Donald Pinkel. Retrieved March 14, 2009 (Dr. Donald Pinkel, pediatrician, has received numerous recognitions for his contributions to the cure of childhood leukemia and other forms of pediatric cancer. These include international awards: the Lasker Award for Medical Research, the Kettering Prize for Cancer Research and the Pollin Prize for Pediatric Research).
- ^ "Dr. Donald Pinkel," St. Jude Children's Research Hospital.
- ^ Four Physicians Honored for Their Historic Contributions to the Treatment of Pediatric Leukemia - New York Presbyterian Hospital. December 19, 2003, accessed March 14, 2009 (The 2003 Pollin Prize, the sole international award for advances in children's health care, is awarded to Drs. Emil Frei, Emil J. Freireich, Donald Pinkel, and James F. Holland. An awards ceremony takes place today at NewYork-Presbyterian Hospital).
- ↑ St. Jude Children's Research Hospital: St. Jude names research tower for Donald Pinkel, MD, in honor of his legacy of finding cures for childhood cancers, March 21, 2017. Retrieved May 31, 2017
| personal data | |
|---|---|
| SURNAME | Pee, Donald |
| ALTERNATIVE NAMES | Pee, Donald Paul |
| BRIEF DESCRIPTION | American hematologist and oncologist |
| DATE OF BIRTH | September 7, 1926 |
| PLACE OF BIRTH | Buffalo , USA |