Doripenem
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Non-proprietary name | Doripenem | |||||||||||||||
other names |
Doripenemum ( Latin ) |
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Molecular formula | C 15 H 24 N 4 O 6 S 2 | |||||||||||||||
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Molar mass | 420.50 g · mol -1 | |||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Doripenem is an antibiotic active substance from the group of carbapenems . Doripenem was approved in Europe from July 2008 to July 2014 ( trade name Doribax ) for the treatment of nosocomial pneumonia, including ventilation pneumonia , complicated infections of the abdomen ( intrabdominal infections) and complicated urinary tract infections . The market withdrawal in 2014 took place after the license rights were returned to the Japanese pharmaceutical company Shionogi .
pharmacology
The mode of action corresponds to that of the carbapenems . By introducing a β-methyl group in position 4, doripenem, in contrast to imipenem, is stable to dehydropeptidase I. It is administered intravenously as a continuous infusion.
Spectrum of activity
Doripenem shows a stronger activity against gram-positive cocci than meropenem and a stronger activity against gram-negative rods than imipenem. Study data show a particularly good effect against Pseudomonas aeruginosa and enterobacteria, including strains that are resistant to other antibiotics.
Side effects
Doripenem was well tolerated in all clinical studies. With regard to safety, a comparable profile to meropenem has been demonstrated for doripenem in clinical studies. The most common side effects that can occur are headache, diarrhea and nausea.
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ a b Public Assessment Report (EPAR) of the European Medicines Agency (EMA) on: Doribax .
- ↑ doripenem - withdrawal in Germany , Pharmaceutical newspaper, online edition 12/2014.
- ↑ M. Mori; M. Hikida; T. Nishihara; T. Nasu; S. Mitsuhashi: Comparative stability of carbapenem and penem antibiotics to human recombinant dehydropeptidase-I , Journal of Antimicrobial Chemotherapy 37, 1034-1036, 1996.
- ↑ Shazad Mushtaq; Yigong Ge; David M. Livermore: Doripenem versus Pseudomonas aeruginosa In Vitro: Activity against Characterized Isolates, Mutants, and Transconjugants and Resistance Selection Potential , Antimicrobial Agents and Chemotherapy 48, 3086-3092, 2004, doi : 10.1128 / AAC.48.8.3086-3092.2004 .