Meropenem

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Structural formula
Structure of meropenem
General
Non-proprietary name Meropenem
other names

Latin : Meropenemum

Molecular formula C 17 H 25 N 3 O 5 S
Brief description

white to pale yellow, crystalline powder (meropenem trihydrate)

External identifiers / databases
CAS number
  • 96036-03-2 ( meropenem )
  • 119478-56-7 (meropenem · tri hydrate )
EC number 641-424-1
ECHA InfoCard 100.169.299
PubChem 441130
ChemSpider 389924
DrugBank DB00760
Wikidata Q421670
Drug information
ATC code

J01 DH02

Drug class

β-lactam antibiotics , carbapenems

Mechanism of action

Inhibition of cell wall synthesis

properties
Molar mass 383.46 g · mol -1
solubility

sparingly soluble in water, very sparingly soluble in dilute ethanol , practically insoluble in acetone and diethyl ether (trihydrate)

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 315-319-335
P: ?
Toxicological data

2650 mg kg −1 ( LD 50 ,  mouse ,  iv )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Meropenem is a drug that belongs to the group of carbapenems and is sold by AstraZeneca .

pharmacology

See carbapenems , unlike imipenem , meropenem is stable to dehydropeptidase I.

Spectrum of activity

The spectrum of activity is greater in the area of ​​gram-negative bacteria compared to imipenem .

Side effects

The side effects largely correspond to those of penicillins and cephalosporins . However, epileptic seizures can also occur.

Trade names

Monopreparations

Meronem (D, CH), Optinem (A)

Web links

Individual evidence

  1. ^ A b The Merck Index : An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006, p. 1018; ISBN 978-0-911910-00-1 .
  2. ↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . What is shown is a label of (4R, 5S, 6S) -3 - [[(3S, 5S) -5 - [(dimethylamino) carbonyl] -3-pyrrolidinyl] thio] -6 - [(1R ) -1-hydroxyethyl] -4-methyl-7-oxo-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylic acid in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on July 8 2020.
  3. ↑ Entry on meropenem in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on July 8, 2020.