Endometrial hyperplasia
| Classification according to ICD-10 | |
|---|---|
| N85.0 | Endometrial hyperplasia |
| ICD-10 online (WHO version 2019) | |
The endometrial hyperplasia (from Greek endo- ένδον, inside , metrium μήτρα, uterus , Hyper ΰπερ above , addition, hyperplasia πλασις forming ) is a localized or generalized increase in size ( hyperplasia ) of the uterine lining ( endometrium ). In contrast to hypertrophy , the increase in size in hyperplasia is caused by an increase in the number of cells.
Mechanism of origin
It arises from sustained stimulation of the mucous membrane by estrogens in the absence of simultaneous stimulation by gestagens . Accordingly, diseases associated with pathologically increased estrogen production promote the development of endometrial hyperplasia. These include follicular persistence , polycystic ovarian syndrome and estrogen-producing tumors (usually originating in the ovaries).
Classification
The simple hyperplasia consists of cystic extended mucous glands (Swiss cheese pattern) with plenty of connective tissue ( stroma ) between the glands.
The complex hyperplasia is characterized by an increase in the glandular-stroma ratio. In addition, the glands are made more irregular due to branches and buds.
The atypical hyperplasia has in addition to the changes in tissue architecture changes at the cellular level to: rounded, pale nuclei , large nucleoli .
forecast
Depending on the microscopic image, the three forms tend to different degrees to degenerate into a malignant growth form. 1% of simple, 3% of complex and 10–30% of atypical hyperplasias develop into a malignant ulcer.
Veterinary medicine
A glandular-cystic hyperplasia of the endometrium is especially for dogs , lagomorphs and guinea pig-like relatively common.
Literature and Sources
- Pschyrembel: Clinical Dictionary. 258th edition. de Gruyter, Berlin 1998, ISBN 3-11-014824-2 .
- W. Böcker, H. Denk, Ph. U. Heitz: Pathology. 2nd Edition. Urban & Fischer, Munich 2008, ISBN 978-3-437-43401-3
