Exercise Induced Collapse

The Labrador Retriever is the breed most commonly affected by Exercise Induced Collapse

Exercise Induced Collapse (EIC) is an inherited neuromuscular disorder that has been observed in certain breeds of dogs .

Symptoms

Dogs affected by EIC can tolerate light to moderate exertion with no problem. However, after prolonged vigorous exertion (from around 20 minutes), they develop an unnatural unsteady gait , mostly starting from the hindquarters , which can spread to the forehand and intensify until the animal collapses . During such episodes , most dogs appear clear and painless, but a clouded consciousness is occasionally described. After about 5 to 25 minutes of rest, the animals usually recover completely.

Occurrence

EIC occurs mainly in the Labrador Retriever , but has also been observed in a few other dog breeds (previously: Chesapeake Bay Retriever , Curly Coated Retriever , Boykin Spaniel , Welsh Corgi Pembroke, and German Wirehaired Pointer ). Dogs from work or field trial breeding lines as well as those from show lines seem to be affected in the same way . There is no connection with the sex or the color of the fur of the animals. Most affected dogs are between six and three years old at the time of initial diagnosis.

genetics

It has been known since 2007 that the mutation responsible for EIC is located on chromosome 9. It is a mutation of the gene for Dynamin-1 (DNM-1).

Diagnosis

Until a DNA test was available in 2008, EIC could only be determined by excluding all other diseases with similar symptoms, such as heat stroke , malignant hyperthermia , CNM or certain forms of epilepsy . The mutation of the DNM-1 gene responsible for EIC can be detected by genetic testing.

therapy

No established therapy is currently known, but in some cases an improvement has been described after administration of phenobarbital . Animals affected by EIC should generally not be exposed to extreme stress, but can easily be kept as family dogs. Species-appropriate training ( retrieving or dummy training , agility , jogging ) is usually possible. In any case, the dog must be kept calm when the first symptoms of an EIC episode appear.

Effects on Breeding

EIC is an autosomal - recessive inherited , that is, dogs can only manifest if they have inherited the corresponding gene mutation from both parents ( " homozygous affected", "affected" or "E / E"). If the gene mutation inherited from only one parent ("carrier", "carrier" or "N / E"), the dog in question cannot become ill itself, but depending on the pairing, its offspring can also be carriers or even affected animals. Dogs that have not inherited the mutation from any of their parents (“free”, “clear” or “N / N”) can neither become ill themselves nor can EIC-affected dogs be among their offspring.

As long as it is ensured that one of the two parent animals is free of EIC (“clear” or “N / N”), carriers and even affected animals can be used for breeding. Neither the Veterinary Diagnostics Laboratory of the University of Minnesota (developer of the genetic test) nor the breeding associations recommend the exclusive mating of N / N animals, as this would also remove many of the desired characteristics of N / E and E / E animals from breeding taken out.

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1. ↑ ^{a b c d e} EIC FAQ - Exercise Induced Collapse in Labrador Retrievers and Related Breeds . Veterinary Diagnostics Laboratory, University of Minnesota. Archived from the original on November 8, 2011. Retrieved April 9, 2020.
2. ↑ KM Minor, EE Patterson, MK Keating, SD Gross, KJ Ekenstedt, SM Taylor, JR Mickelson: Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds. In: Veterinary journal (London, England: 1997). Volume 189, Number 2, August 2011, pp. 214-219, ISSN  1532-2971 . doi: 10.1016 / j.tvjl.2011.06.022 . PMID 21782486 .
3. Jump up ↑ EE Patterson, KM Minor, AV Tchernatynskaia, SM Taylor, GD Shelton, KJ Ekenstedt, JR Mickelson: A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. In: Nature genetics . Volume 40, Number 10, October 2008, pp. 1235-1239, ISSN  1546-1718 . doi: 10.1038 / ng.224 . PMID 18806795 .
4. ↑ Exercise Induced Collapse in Labrador Retrievers (PDF; 153 kB) Taylor, SM. Retrieved February 11, 2012.
5. ^ Exercise Induced Collapse (EIC) in Labrador Retrievers and related breeds . German Retriever Club. Retrieved February 11, 2012.

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !