Experimental pharmacology
The experimental pharmacology is a scientific - medical field within the pharmacology . In experimental pharmacology, model systems are used to try to simulate the pharmacological properties of a (potential) drug or a drug preparation . These examinations usually take place before the medicinal product is clinically tested .
Methods
The test methods used in experimental pharmacology include both in vitro and in vivo tests. Both drug tests on enzymes , cell cultures and tissue samples as well as animal experiments are carried out.
Using radiopharmaceutical methods, metabolic pathways can be investigated in pharmacologically ineffective low dosages.
Important pharmacologists
Important contributions in the field of experimental pharmacology were made by a .:
- Sir Henry Hallett Dale ( Nobel Prize winner , discoverer of the function of various transmitters)
- Paul Ehrlich (Nobel Prize Winner, coined the term " receptor ", inventor of arsphenamine )
- Alfred Joseph Clark (founder of the receptor theory based on the law of mass action )
- Everhardus Jacobus Ariëns (receptor theory, enantiomerically pure medicinal substances)
- Sir Alexander Fleming (Nobel Prize Winner, discoverer of penicillins )
- Heinz Otto Schild (receptor theory, Schild plot )
- Sir John Robert Vane (Nobel Prize Winner, discoverer of the mechanism of action of acetylsalicylic acid )
- Albert Hofmann (inventor of LSD)
- Sir James Whyte Black (Nobel Prize Winner, Inventor of Beta Blockers , Contribution to Receptor Theory (Operational Model))
- Alfred Goodman Gilman (Nobel Prize Winner, Discovery of G-Proteins )
- Robert Francis Furchgott (Nobel Prize Winner, contribution to receptor theory, discoverer of the EDRF)