Heinz Otto sign

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Heinz Otto Schild (born May 18, 1906 in Rijeka , Austria-Hungary , † June 15, 1984 ) was an Austrian pharmacologist . He made important contributions to the function of receptors and the mathematical description of the ligand -receptor interaction. The Schild plot , a graphical-mathematical method for determining the affinity of a ligand for the receptor, was named after him.

Life

youth

Heinz Otto Schild grew up in Fiume (now Rijeka), which at that time belonged to Austria-Hungary. After the fall of the Habsburg monarchy , his family moved to Munich in 1921 , where he graduated from the Wilhelmsgymnasium in 1925 and then studied medicine.

Research activity

1932 Heinz Otto shield moved to England to the London laboratory of Henry H. Dale to investigate. After a stopover in Edinburgh , he returned to London in 1937 to work at University College London . Here, Heinz Otto Schild devoted himself to researching the receptor function and the mathematical description of the ligand-receptor interaction. Heinz Otto Schild remained in England throughout his life, with the exception of the years 1939–1940, when he was interned on the Isle of Wight because of his Italian citizenship and the beginning of the Second World War .

In 1947 he introduced the p A 2 value , with which the potency of an antagonist can be determined independently of the concentration , and a mathematical-graphic method for its determination (Schild plot). With the help of this method, it was also possible for the first time to indirectly determine the affinity of a ligand for the receptor.

The German Pharmacological Society awarded him their highest honor in 1977 with the Schmiedeberg plaque .

literature

  • Black J. (1994). Heinz Otto Schild - 18 May 1906-15 June 1984. Biogr. Mem. Fellows R. Soc. 39: 383-415.
  • Colquhoun D. (2006). The quantitative analysis of drug-receptor interactions: a short history. Trends Pharmacol. Sci. 27: 149-157.

Individual evidence

  1. ^ Annual report on the Wilhelms-Gymnasium in Munich. ZDB ID 12448436 , 1924/25
  2. ^ Schild H. O. (1947). PA, a new scale for the measurement of drug antagonism. Br. J. Pharmacol. 2: 189-206.
personal data
SURNAME Schild, Heinz Otto
BRIEF DESCRIPTION Austrian pharmacologist
DATE OF BIRTH May 18, 1906
PLACE OF BIRTH Rijeka , Austria-Hungary
DATE OF DEATH June 15, 1984