Factor VII Activating Protease
| Factor VII Activating Protease | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 537 = 290 + 247 amino acids | |
| Secondary to quaternary structure | Heterodimer | |
| Identifier | ||
| Gene names | HABP2 ; HABP, PHBP, HGFAL, FSAP | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.4.21. , Serine protease | |
| MEROPS | S01.033 | |
| Substrate | Factor VII | |
| Products | Factor VIIa | |
| Occurrence | ||
| Homology family | HGF Activator | |
| Parent taxon | Euteleostomi | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 3026 | 226243 |
| Ensemble | ENSG00000148702 | ENSMUSG00000025075 |
| UniProt | Q14520 | Q8K0D2 |
| Refseq (mRNA) | NM_001177660 | NM_146101 |
| Refseq (protein) | NP_001171131 | NP_666213 |
| Gene locus | Chr 10: 113.55 - 113.59 Mb | Chr 19: 56.29 - 56.32 Mb |
| PubMed search | 3026 |
226243
|
The factor VII-activating protease (FSAP, hyluronan-binding protein 2) is a serine protease that has only recently been discovered. FSAP ( Engl. Factor VII-activating protease ) has two important functions in the system of hemostasis . On the one hand, it activates factor VII to form factor VIIa and thus starts the plasmatic coagulation of the blood . On the other hand, it is also an activator for certain plasminogen activators, in particular for prourokinase, a precursor of urokinase . The enzyme plasmin is at the end of this activation chain and is able to dissolve a fibrin clot again. A defect in the gene that codes for FSAP is known as Marburg I polymorphism . This defect could theoretically lead to an insufficient activation of plasminogen activators, which in turn could result in an increased tendency to thrombotic events . This theory was supported by Hoppe et al. proven in a study. Van Minkelen et al. Found no connection between Marburg I polymorphism and thrombotic events in their own study. They traced Hoppe's results back to their selection criteria for the study participants in the groups of patients and control persons.
Representation of activation
FSAP
↓
u-PA ← Pro u-PA
↓
Plasminogen → Plasmin
↓
Fibrin → Fibrinspaltprodukte
literature
- J. Römisch: Factor VII activating protease (FSAP): a novel protease in hemostasis. In: Biol Chem . 383, 2002, pp. 1119-1124.
- J. Römisch, S. Vermöhlen, A. Feussner, H. Stöhr: The FVII activating protease cleaves single-chain plasminogen activators. In: Haemostasis. 29 (5), 1999, pp. 292-299.
Individual evidence
- ↑ B. Hoppe, F. Tolou, H. Radtke, H. Kiesewetter, T. Dorner, A. Salama: Marburg I polymorphism of factor VII-activating protease is associated with idio-pathic venous thromboembolism. In: Blood . 105 (4), 2005, pp. 1549-1551.
- ↑ R. van Minkelen, MC de Visser, HL Vos, RM Bertina, FR Rosendaal: The Marburg I polymorphism of factor VII-activating protease is not associated with venous thrombosis. In: Blood. 105 (12), 2005, p. 4898; author reply 4899.