GRIA 3
Glutamate receptor, ionotrophic, AMPA 3 | ||
---|---|---|
Properties of human protein | ||
Mass / length primary structure | 866 amino acids | |
Secondary to quaternary structure | multipass membrane protein; Homo- / heterotetramer | |
Isoforms | Flip, flop | |
Identifier | ||
Gene names | GRIA3 ; GluR-3, GluR-C, AMPA-3 | |
External IDs | ||
Transporter classification | ||
TCDB | 1.A.10 | |
designation | Glutamate-gated ion channel | |
Occurrence | ||
Homology family | Glutamate receptor | |
Parent taxon | Bilateria | |
Orthologue | ||
human | mouse | |
Entrez | 2892 | 53623 |
Ensemble | ENSG00000125675 | ENSMUSG00000001986 |
UniProt | P42263 | Q0VGS8 |
Refseq (mRNA) | NM_000828 | NM_016886 |
Refseq (protein) | NP_000819 | NP_058582 |
Gene locus | Chr X: 122.15 - 122.45 Mb | Chr X: 37.65 - 37.92 Mb |
PubMed search | 2892 |
53623
|
The ionotropic glutamate receptor AMPA 3 (Syn. GRIA3) belongs to the group of AMPA receptors . It's a human protein .
Glutamate receptors are among the predominant excitatory neurotransmitter receptors in the mammalian brain. They are heteromeric protein complexes that consist of different subunits. Each subunit has a transmembrane domain. Together they form a ligand-gated ion channel. The glutamate receptors of the type GRIA 1-4 (also GluR1-4) belong to the so-called AMPA receptors because they can be activated by the agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate . GRIA 3 is also expressed on lymphocytes and has been traded as a candidate gene for various disorders, including Rett syndrome, Rasmussen encephalitis, bipolar disorder and Smith-Fineman-Myers X-linked mental redardation syndrome.
Recommended literature
- McNamara JO, Eubanks JH, McPherson JD, et al. : Chromosomal localization of human glutamate receptor genes. in: J. Neurosci. vol. 12.7 pg. 2555-62 (1992) PMID 1319477
- Hollmann M, Hartley M, Heinemann S: Ca2 + permeability of KA-AMPA - gated glutamate receptor channels depends on subunit composition. in: Science vol. 252,5007 pg. 851-3 (1991) PMID 1709304
- Rampersad V, Elliott CE, Nutt SL, et al. : Human glutamate receptor hGluR3 flip and flop isoforms: cloning and sequencing of the cDNAs and primary structure of the proteins. in: Biochim. Biophys. Acta vol. 1219.2 pg. 563-6 (1994) PMID 7918660
- Tomiyama M, Rodriguez-Puertas R, Cortés R, et al. : Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization. in: Neuroscience vol. 75.3 pg. 901-15 (1997) PMID 8951883
- Osten P, Srivastava S, Inman GJ, et al. : The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs. in: Neuron vol. 21.1 pg. 99-110 (1998) PMID 9697855
- Srivastava S, Osten P, Vilim FS, et al. : Novel anchorage of GluR2 / 3 to the postsynaptic density by the AMPA receptor-binding protein ABP. in: Neuron vol. 21.3 pg. 581-91 (1998) PMID 9768844
- Hayashi T, Umemori H, Mishina M, Yamamoto T: The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn. in: Nature vol. 397.6714 pg. 72-6 (1999) PMID 9892356
- Aruscavage PJ, Bass BL: A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing. in: RNA vol. 6.2 pg. 257-69 (2000) PMID 10688364
- Gahring L, Carlson NG, Meyer EL, Rogers SW: Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation. in: J. Immunol. vol. 166.3 pg. 1433-8 (2001) PMID 11160179
- Hirbec H, Perestenko O, Nishimune A, et al. : The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. in: J. Biol. Chem. vol. 277.18 pg. 15221-4 (2002) PMID 11891216
- Wyszynski M, Kim E, Dunah AW, et al. : Interaction between GRIP and liprin-alpha / SYD2 is required for AMPA receptor targeting. in: Neuron vol. 34.1 pg. 39-52 (2002) PMID 11931740
- Tomiyama M, Rodríguez-Puertas R, Cortés R, et al. : Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis. in: Synapse vol. 45.4 pg. 245-9 (2002) PMID 12125045
- Strausberg RL, Feingold EA, Grouse LH, et al. : Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. in: Proc. Natl. Acad. Sci. USA vol. 99.26 pg. 16899-903 (2003) PMID 12477932
- Flajolet M, Rakhilin S, Wang H, et al. : Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. in: Proc. Natl. Acad. Sci. USA vol. 100.26 pg. 16006-11 (2004) PMID 14663150
- Kolleker A, Zhu JJ, Schupp BJ, et al. : Glutamatergic plasticity by synaptic delivery of GluR-B (long) -containing AMPA receptors. in: Neuron vol. 40.6 pg. 1199-212 (2004) PMID 14687553
Individual evidence
- ↑ Entrez Gene: GRIA3 glutamate receptor, ionotrophic, AMPA 3 . Retrieved December 31, 2010.
- ↑ Ganor Y, Besser M, Ben-Zakay N, et al. : Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration. in: J. Immunol. vol. 170.8 pg. 4362-72 (2003) PMID 12682273
- ↑ Amir R, Dahle EJ, Toriolo D, Zoghbi HY: Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq. in: Am. J. Med. Genet. vol. 90.1 pg. 69-71 (2000) PMID 10602120
- ↑ Rogers SW, Andrews PI, Gahring LC, et al. : Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis. in: Science vol. 265.5172 pg. 648-51 (1994) PMID 8036512
- ↑ Gécz J, Barnett S, Liu J, et al. : Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation. in: Genomics vol. 62.3 pg. 356-68 (2000) PMID 10644433
- ↑ Liu QJ, Gong YQ, Chen BX, et al. : [Linkage analysis and mutation detection of GRIA3 in Smith - Fineman - Myers syndrome] in: Yi Chuan Xue Bao vol. 28.11 pg. 985-90 (2001) PMID 11725645