Georg von Boyen

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Georg Bruno Theodor von Boyen (born January 2, 1970 in Erlangen ) is a German physician and professor of internal medicine . He is the medical director of the Sigmaringen district clinics and chief physician of the medical clinic. Von Boyen is best known for his research on complications and therapy of inflammatory bowel disease, the role of the enteric nervous system in maintaining bowel homeostasis, and genetic disorders of inflammatory bowel disease.

Life

Von Boyen studied medicine at the Ruprecht-Karls-Universität Heidelberg (1990–1997). As an intern and resident doctor, von Boyen worked from 1998 to 2000 in addition to his clinical work on projects to characterize the enteric nervous system. In ongoing work in 2000, enteric glia turned out to be an essential part of his scientific work. The focus on enteric glia in connection with inflammatory processes of the intestine led to a move to the Clinic for Internal Medicine I at the Ulm University Hospital . In 2005, von Boyen was recognized as a specialist in internal medicine. In 2007 he was awarded the venia legendi for the subject of internal medicine and, with continued scientific work, specialist lectures and teaching, he was appointed adjunct professor at Ulm University in 2013. Von Boyen has been the chief physician of the medical clinic at the SRH clinics in Sigmaringen and Pfullendorf since 2011. In 2017 he was appointed medical director of the SRH clinics Sigmaringen with the clinics Sigmaringen, Bad Saulgau and Pfullendorf.

Scientific contribution

As part of his doctoral thesis at Heidelberg University, von Boyen dealt with volumetric measurements of the central nervous system as a diagnostic tool for differentiating dementias . With a detailed analysis of the nervous system in scientific reviews, his further research focused on the nervous system of the intestine: the enteric nervous system (ENS) . In the scientific working group of the University Hospital Mannheim, von Boyen was able to prove that a heterozygous deficiency of the endothelin B receptor leads to a defined disturbance of the ENS. When he moved to Ulm University Hospital, von Boyen initially developed primary cultures of the ENS in a research group. With the early work on this model, he was one of the first to investigate the enteric glia as an important cell population in the intestine and to characterize its behavior under inflammatory conditions of the intestine. With the establishment of his own research group under his most important sponsor Guido Adler , von Boyen showed in several scientific papers the essential role of enteric glia in modulating inflammation and as a source for maintaining intestinal integrity. With the evidence of the changed glial populations in Crohn's disease and ulcerative colitis, he underlined the importance of the intestinal nervous system in maintaining intestinal homeostasis in the human body and as a possible piece of the puzzle in understanding the pathophysiology of chronic inflammatory bowel diseases . In addition to the basic research, von Boyen also took part in clinical studies to investigate the NOD2 mutation as a risk factor in the therapy decision of patients with Crohn's disease and the connection between chronic intestinal inflammation and osteoporosis .

Memberships in scientific associations

Von Boyen is a member of various scientific associations. These include: German Society for Digestive and Metabolic Diseases , Working Group Neurogastroenterology and Motility e. V., Southwest German Society for Gastroenterology and German Society for Ultrasound in Medicine (DEGUM) .

Publications

Web links

Individual evidence

  1. ↑ Ambulance / consultation hours. Clinics in the district of Sigmaringen, accessed on June 7, 2017 .
  2. ↑ Former senior physicians. (No longer available online.) Ulm University Hospital, archived from the original on May 26, 2017 ; accessed on June 7, 2017 . Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.uniklinik-ulm.de
  3. ↑ Christoph Wartenberg: Change of staff: Dr. von Boyen takes over department. Schwäbische.de, July 7, 2011, accessed June 7, 2017 .
  4. ↑ Georg von Boyen is now Medical Director in Sigmaringen. In: Südkurier. February 21, 2017. Retrieved June 7, 2017 .
  5. ↑ GB von Boyen, M. Reinshagen, M. Steinkamp, ​​G. Adler, J. Kirsch: Enteric nervous plasticity and development: dependence on neurotrophic factors. In: J Gastroenterol. 37, 2002, pp. 583-588.
  6. ↑ GB von Boyen, M. Reinshagen, M. Steinkamp, ​​G. Adler, J. Kirsch: Gut inflammation modulated by the enteric nervous system and neurotrophic factors. In: Scand J Gastroenterol. 37, 2002, pp. 621-625.
  7. ↑ GB von Boyen, HJ Krammer, A. Suss, C. Dembowski, H. Ehrenreich, T. Wedel: Abnormalities of the enteric nervous system in heterozygous endothelin B receptor deficient (spotting lethal) rats resembling intestinal neuronal dysplasia. In: Good. 51, 2002, pp. 414-419.
  8. ↑ GB von Boyen, M. Steinkamp, ​​M. Reinshagen, KH Schäfer, G. Adler, J. Kirsch: Proinflammatory cytokines increase GFAP expression in enteric glia. In: Good. 53, 2004, pp. 222-228.
  9. ↑ GB von Boyen, M. Steinkamp, ​​M. Reinshagen, KH Schafer, G. Adler, J. Kirsch: Nerve Growth Factor (NGF) secretion in cultured enteric glia cells is modulated by proinflammatory cytokines. In: J Neuroendocrinol. 18, 2006, pp. 820-825.
  10. ↑ M. Steinkamp, ​​N. Schulte, H. Gundel, U. Spaniol, J. Kirsch, G. von Boyen: GDNF protects apoptosis in enteric glia: Evidence for an autocrine loop. In: BMC Gastroenterol. 12, 17th Jan 2012, p. 6. doi: 10.1186 / 1471-230X-12-6 .
  11. ↑ GB von Boyen, M. Steinkamp, ​​I. Geerling, M. Reinshagen, KH Schäfer, G. Adler, J. Kirsch: Proinflammatory cytokines induce neurotrophic factor expression in enteric glia: a key to the regulation of epithelial apoptosis in Crohn's disease. In: Inflamm Bowel Dis. 12, 2006, pp. 346-354.
  12. ↑ M. Steinkamp, ​​I. Geerling, T. Seufferlein, G. von Boyen, B. Egger, J. Grossmann, L. Ludwig, G. Adler, M. Reinshagen: Glial-derived neurotrophic factor regulates apoptosis in colonic epithelial cells. In: Gastroenterology. 124, 2003, pp. 1748-1757.
  13. ↑ G. von Boyen, N. Degenkolb, C. Hartmann, G. Adler, M. Steinkamp: The endothelin axis influences enteric glia cell functions. In: Med Sci Mon. 2010; 16: BR161-7.
  14. ↑ G. von Boyen, N. Schulte, C. Pflüger, U. Spaniol, C. Hartmann, M. Steinkamp: Distribution of enteric glia and GDNF during gut inflammation. In: BMC Gastroenterol. 11, 2011, p. 3.
  15. ↑ G. von Boyen, M. Reinshagen: The enteric glia part of the puzzle in Crohn's disease. In: Z Gastroenterol. 49, 2011, pp. 1482-1486. doi: 10.1055 / s-0031-1281672 .
  16. ↑ C. Posovszky, V. Pfalzer, G. Lahr, K.-M. Debatin, G. von Boyen: Influence Of Nod2 / Card15 Gene Variants On Disease Activity, Bone Mineral Density And Response To Therapy In Crohn'S Disease With Pediatric Onset. In: BMC Gastroenterol. 13, 2013, p. 77. doi: 10.1186 / 1471-230X-13-77 .
  17. ↑ J. Niess, C. Pflüger, N. Schulte, J. Klaus, U. Spaniol, G. Lahr, G. von Boyen: Influence of NOD2 mutations on the response to standard treatments of Crohn's disease patients. In: Dig Dis Sci. 57, 2012, pp. 879-886.
  18. ↑ J. Klaus, M. Reinshagen, K. Herdt, C. Schröter, G. Adler, GB von Boyen, C. von Tirpitz: Bones and crohn's: No benefit of adding sodium fluoride or ibandronate to calcium and vitamin D. In: World J Gastroenterol. 17, 2011, pp. 334-342.
  19. ↑ J. Klaus, MM Hänle, C. Schröter, G. Adler, G. von Boyen, M. Reinshagen, C. von Tirpitz: A Single Dose of Intravenous Zoledronate Prevents Glucocorticoid Therapy-Associated Bone Loss in Acute Flare of Crohn's Disease, a Randomized Controlled Trial. In: Am J Gastroenterol. 106, 2011, pp. 786-793.
personal data
SURNAME Boyen, Georg von
ALTERNATIVE NAMES Boyen, Georg Bruno Theodor von
BRIEF DESCRIPTION German specialist in internal medicine
DATE OF BIRTH 2nd January 1970
PLACE OF BIRTH gain