Gert Fricker

Gert Fricker

Gert Wilhelm Mathias Fricker (born June 5, 1956 in Ludwigshafen am Rhein ) is a German biochemist and professor at Heidelberg University . Gert Fricker is Director at the Institute for Pharmacy and Molecular Biotechnology at the Faculty of Biosciences at Heidelberg University, and has been the Dean of Studies for Pharmacy since 2002. At the IPMB, he heads the Pharmaceutical Technology and Biopharmacy Department. Within the Working Group for Pharmaceutical Process Engineering (APV) he belongs to the training and science specialist group. Together with Michael Wink , he is the managing director of the Steinbeis Transfer Center for Biopharmacy and Analytics in Heidelberg. Fricker is also a co-founder of HeiDelTec GmbH (Heidelberg Delivery Technologies).

Career

From 1975 to 1981 Gert Fricker studied chemistry and medicine at the University of Freiburg . In 1986 he was awarded a doctorate in chemistry at the Faculty of Chemistry and Pharmacy, Department of Biochemistry. rer. nat. PhD . He then worked for two years as a postdoc at the University Hospital Zurich . In 1988 G. Fricker switched to industry and went to Sandoz in Basel. There he worked in the Drug Delivery Systems department . During his time in Basel he was in Freiburg in the field of experimental medicine habilitation . In 1995 Gert Fricker accepted a call from Heidelberg University and became a professor at the Institute for Pharmaceutical Technology and Biopharmacy. In 2002 he became director at the Institute for Pharmacy and Molecular Biotechnology at Heidelberg University. In 2014 he was a visiting professor at the Eugene-Applebaum College of Pharmacy and Health Sciences at Wayne State University , Detroit , Michigan, USA. Furthermore, Fricker has been working as a visiting principal investigator at the Mount Desert Island Biological Laboratory , Salsbury Cove, Maine , USA, since 1985 .

Work areas

Gert Fricker and his working group deal with the topics of drug delivery (especially through the blood-brain barrier or choroid plexus ), drug targeting , membrane transport , improving the absorption of active ingredients and bioavailability , as well as the function and influence of the ABC transporters . Of technological relevance are u. a. Work in the field of micro and nanoparticles , liposomes and microemulsions. The group around Gabriele Reich belongs to the working group , which focuses on soft gelatine capsules , Process Analytical Technology (PAT), near-infrared spectroscopy (NIRS) and depot pharmaceutical forms based on innovative biopolymers . G. Fricker organizes the annual barrier and transporter meeting in Bad Herrenalb.

Courses

Gert Fricker teaches pharmacy and molecular biotechnology at Heidelberg University.

• Biopharmacy (pharmacy)
• Pharmaceutical Technology (Pharmacy)
• Lecture series drug research (molecular biotechnology)
• Nutrition (pharmacy)

Membership in scientific societies

• German Pharmaceutical Society (DPhG)
• Working Group for Pharmaceutical Process Engineering (APV)
• American Association of Pharmaceutical Scientists (AAPS)
• Controlled Release Society, German Section (CRS)
• Lifetime Member of the Mount Desert Island Biological Laboratory, Salsbury Cove, ME, USA
• European Intestinal Transport Group (EITG)
• International Blood Brain Barrier Society (IBBS)
• Yale Liver Center

Prizes and awards

• 1998: Science award from the International Association of Pharmaceutical Technology (APV) for outstanding research in pharmacy
• 2003: Dietrich Schmähl Prize of the Central European Society for Anticancer Research CESAR (overcoming p-glycoprotein at the blood brain barrier)
• 2003: Phoenix Pharmacy Prize for Excellence in Pharmaceutical Pharmacology (taxol treatment of brain tumors)
• 2009: Phönix Pharmacy Prize for Excellence in Pharmaceutical Technology (nanoparticles for CNS targeting)

Publications (selection)

• with P. Langguth and H. Wunderli-Allenspach: Biopharmazie. Wiley-VCH, Weinheim 2004, ISBN 3-527-30455-X .
• with M. Ott and A. Mahringer: The Blood Brain Barrier (BBB). Springer, Heidelberg 2014, ISBN 978-3-662-43786-5 .
• with T. Köthe, S. Martin, G. Reich: Dual asymmetric centrifugation as a novel method to prepare highly concentrated dispersions of PEG-b-PCL polymersomes as drug carriers. in International Journal of Pharmaceutics . Volume 579, 2020, 119087, doi : 10.1016 / j.ijpharm.2020.119087 .
• with A. Zaremba, F. Helm: Impact of Zn2 + on ABC Transporter Function in Intact Isolated Rat Brain Microvessels, Human Brain Capillary Endothelial Cells, and in Rat in Vivo. in Molecular Pharmaceutics . Volume 16 (1), 2019, pp. 305-317, doi : 10.1021 / acs.molpharmaceut.8b00987 .
• with A. Mahringer, A. Bernd, DSMiller: Aryl hydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish (Fundulus heteroclitus) renal proximal tubules. in Biological Chemistry . Volume 400, 2019, pp. 1335-1345, doi : 10.1515 / hsz-2018-0425 .
• with A. Zaremba, DS Miller: Zinc chloride rapidly stimulates efflux transporters in renal proximal tubules of killifish (Fundulus heteroclitus). in Toxicology and Applied Pharmacology . 2017 Sep 4th pii: S0041-008X (17) 30367-8. doi : 10.1016 / j.taap.2017.09.001
• with P. Uhl, S. Pantze, P. Storck, J. Parmentier, D. Witzigmann, G. Hofhaus, J. Huwyler, W. Mier: Oral delivery of vancomycin by tetraether lipid liposomes. in European Journal of Pharmaceutical Sciences . Volume 108, 2017, pp. 111-118, doi : 10.1016 / j.ejps.2017.07.013 .
• with A. Mahringer: ABC transporters at the blood-brain barrier. in Expert Opinion on Drug Metabolism & Toxicology . Volume 12, number 5, 2016, pp. 499-508, doi : 10.1517 / 17425255.2016.1168804 .
• with J. Parmentier, G. Hofhaus, S. Thomas, LC Cuesta, F. Gropp, R. Schröder, K. Hartmann: "Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazole . " in Journal of Pharmaceutical Sciences . Volume 103, Number 12, 2014, pp. 3985-3889, doi : 10.1002 / jps.24215 .
• with A. Ćurić A, BL. Keller, R. Reul, J. Möschwitzer: Development and lyophilization of itraconazole loaded poly (butylcyanoacrylate) nanospheres as a drug delivery system. In European Journal of Pharmaceutical Sciences . Volume 78, 2015, pp. 121-131, doi : 10.1016 / j.ejps.2015.07.010 .
• with M. Kolter, M. Ott, C. Hauer and I. Reimold: Nanotoxicity of poly (n-butylcyano-acrylate) nanoparticles at the blood-brain barrier, in human whole blood and in vivo. in Journal of Controlled Release . Volume 10, number 197, 2015, pp. 165–179, doi : 10.1016 / j.jconrel.2014.11.005 .
• with J. Parmentier, B. Thewes and F. Gropp: Oral peptide delivery by tetraether lipid liposomes. In: International Journal of Pharmaceutics . Volume 415, Number 1-2, August 2011, pp. 150-157, ISSN  1873-3476 . doi: 10.1016 / j.ijpharm.2011.05.066 . PMID 21664955 .
• with EA Neuwelt, B. Bauer, C. Fahlke, C. Iadecola, D. Janigro, L. Leybaert, Z. Molnár, ME O'Donnell, JT Povlishock, NR Saunders, F. Sharp, D. Stanimirovic, RJ Watts and LR Drewes: Engaging neuroscience to advance translational research in brain barrier biology. In: Nature Reviews Neuroscience . Volume 12, Number 3, March 2011, pp. 169-182, ISSN  1471-0048 . doi: 10.1038 / nrn2995 . PMID 21331083 . PMC 3335275 (free full text). (Review).
• with A. Mahringer: BCRP at the blood-brain barrier: genomic regulation by 17? -estradiol. In: Molecular Pharmaceutics . Volume 7, Number 5, October 2010, pp. 1835-1847, ISSN  1543-8392 . doi: 10.1021 / mp1001729 . PMID 20735085 .
• with M. Ott, M. Huls and MG Cornelius: St. John's Wort constituents modulate P-glycoprotein transport activity at the blood-brain barrier. In: Pharmaceutical Research . Volume 27, Number 5, May 2010, pp. 811-822, ISSN  1573-904X . doi: 10.1007 / s11095-010-0074-1 . PMID 20229133 .
• with A. Mahringer and J. Delzer: A fluorescence-based in vitro assay for drug interactions with breast cancer resistance protein (BCRP, ABCG2). In: European Journal of Pharmaceutics and Biopharmaceutics Volume 72, Number 3, August 2009, pp. 605-613, ISSN  1873-3441 . doi: 10.1016 / j.ejpb.2009.01.010 . PMID 19572416 .
• with C. MacLean, U. Moenning and A. Reichel: Closing the gaps: a full scan of the intestinal expression of p-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in male and female rats. In: Drug Metabolism and Disposition . Volume 36, Number 7, July 2008, pp. 1249-1254, ISSN  1521-009X . doi: 10.1124 / dmd.108.020859 . PMID 18378562 .
• G. Fricker: Drug interactions with natural products at the blood brain barrier. in: Curr Drug Metab . 9, 2008, pp. 1019-1026. PMID 19075618 (Review)
• with C. Baehr and V. Reichel: Choroid plexus epithelial monolayers - a cell culture model from porcine brain. In: Cerebrospinal Fluid Res. 21, 2006, p. 13. PMID 17184532 , PMC 1774582 (free full text)
• with CH Baehr and DS Miller: Fluorescein-methotrexate transport in dogfish shark (Squalus acanthias) choroid plexus. In: Am J Physiol. 291, 2006, pp. R464-472. PMID 16914433
• with AM Hartz, B. Bauer and DS Miller: Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide. In: Mol Pharmacol . 69, 2006, pp. 462-470. PMID 16278373
• with B. Bauer, AM Hartz and DS Miller: Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. In: Mol Pharmacol. 66, 2004, pp. 413-419. PMID 15322232
• with AM Hartz, B. Bauer and DS Miller: Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1. In: Mol Pharmacol. 66, 2004, pp. 387-394. PMID 15322229
• with B. Bauer and DS Miller: Compound profiling for P-glycoprotein at the blood-brain barrier using a microplate screening system. In: Pharm Res. 20, 2003, pp. 1170-1176. PMID 12948014
• with S. Fellner, B. Bauer, DS Miller, M. Schaffrik, M. Fankhanel, T. Spruss, G. Bernhardt, C. Graeff, L. Farber, H. Gschaidmeier and A. Buschauer: Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. In: J Clin Invest. 110, 2002, pp. 1309-1318. PMID 12417570 , PMC 151606 (free full text)
• with S. Nobmann and DS Miller: Permeability of porcine blood brain barrier to somatostatin analogues. In: Br J Pharmacol . 135, 2002, pp. 1308-1314. PMID 11877340 , PMC 1573221 (free full text)
• with DS Miller, C. Graeff, L. Droulle and S. Fricker: Xenobiotic efflux pumps in isolated fish brain capillaries. In: Am J Physiol Regul Integr Comp Physiol. 282, 2002, pp. R191-198. PMID 11742838
• with J. Drewe, H. Gutmann, M. Torok, C. Beglinger and J. Huwyler: HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833. In: Biochem Pharmacol . 57, 1999, pp. 1147-1152. PMID 11230802

Web links

• Website by Gert Fricker