Glucoprotamine

Structural formula
General
Surname	Glucoprotamine
other names	Reaction products of L - glutamic acid with N - (C 12-14 alkyl) propylenediamine
Molecular formula	C 8 H 14 N 3 O 2 R ; (R = C 12 H 25 to C 14 H 29 )
Brief description	Waxy, not volatile
External identifiers / databases
EC number	403-950-8
ECHA InfoCard	100.100.563
PubChem	381124051
Wikidata	Q69641898
properties
Molar mass	approx. 351.5 to 379.3 g mol −1
solubility	good in water
safety instructions
H and P phrases	H: 302-314-330-400
	P: ?
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Glucoprotamine is a biocide . It is mainly used for effective surface disinfection . The substance is a reaction product of L - glutamic acid and N - (C _12-14 -alkyl) propylenediamine. Glucoprotamin is a registered name of the Ecolab company .

presentation

According to the applicant, glucoprotamine is the reaction product of N - alkyl - 1,3-diaminopropane and L - glutamic acid . The alkyl residues come from saponified coconut oil and contain mainly 12 to 14 carbon atoms each. Coconut oil and glutamic acid are naturally occurring substances.

properties

During the synthesis, glucoprotamine is present as a waxy substance that is readily water-soluble and non- volatile . Glucoprotamine is completely biodegradable according to OECD 301A. It is against gram- positive and gram-negative bacteria, fungi (yeasts), enveloped and non-enveloped viruses effectively, in addition also against mycobacteria non-enveloped and an expanded range of lipophilic viruses. The mycobacteria include u. a. also the causative agent of tuberculosis . Glucoprotamine is odorless and does not evaporate at room temperature. It is not suitable for cleaning instruments made of silicone.

Patenting

Glucoprotamine was registered for a patent by Ecolab in 1985 under the heading “Antimicrobial Substances, Their Manufacture and Use”. Werner Gerhardt, Herbert Fischer, Rudolf Lehmann, Karlheinz Disch and Hans Theo Leinen were registered as inventors in the patent application. The patent has since expired.

use

Glucoprotamine is used to disinfect surfaces and instruments, especially in the medical field such as practices or hospitals.

Commercial products

Incidin , Sekumatic , Sekusept

literature

Glucoprotamin ED - Axel Kramer; Ojan Assadian; Karl H. Wallhäusser: Wallhäusser's practice of sterilization, disinfection, antiseptics and conservation , Stuttgart [UA]: Thieme, January 1, 2008. De, pp. 786–787, ISBN 978-3-13-141121-1 , XP009149508.
Database WPI Week 200004, Derwent World Patents Index; AN 2000-042690, XP002648372.
Database WPI Week 200134, Derwent World Patents Index; AN 2001-320545, XP002648373.
Disch K .: Glucoprotamine - a new antimicrobial substance , Zentralblatt für Hygiene und Umweltmedizin, Stuttgart, DE, vol. 1995, January 1, 1994, pp. 357-365, XP009149509, ISSN 0934-8859 .
S. Tyski, W. Grzybowska, S. Grzeszczuk, P. Leszczynski, M. Staniszewska, E. Röhm, B. Jakimiak: Antimicrobial Activity of Glucoprotamin-Containing Disinfectants , Polish Journal of Microbiology, Vol. 58, no. 4, 2009 , Pp. 347-353, XP002648371.

Web links

Patent WO2012028196A1 : Disinfectants based on glucoprotamin with efficacy against prions
Entry on glucoprotamine in the ChemIDplus database of the United States National Library of Medicine (NLM)

Individual evidence

↑ ^a ^b ^c Newsletter glucoprotamin from the manufacturer Ecolab from February 2016 (pdf, 0.84 MB)
↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of glutamic acid, reaction products with N- (C _12-14 -alkyl) propylenediamine in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on November 16, 2019, is reproduced from a self-classification by the distributor .
↑ Entry on glutamic acid, reaction products with N- (C _12-14 -alkyl) propylenediamine in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on November 16, 2019. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ Website of the Federal Institute for Occupational Safety and Health (accessed on September 15, 2019).
↑ DPMA - register number: 2006107 , accessed on October 4, 2019.
↑ Steber J., Schröder FR: Glucoprotamin® - an antimicrobial agent with favorable degradation properties. Hyg Med 1996; 22: 19-26.
^ B. Meyer, C. Kluin: Efficacy of Glucoprotamin® containing disinfectants against different species of atypical mycobacteria. In: J Hosp Infect. 42, 1999, pp. 151-154.
↑ Website of the German Patent and Trademark Office (accessed on May 24, 2020).
↑ PDF on the reprocessing of vaginal probes on the website of the Robert Koch Institute (accessed on September 19, 2019).

[econews-1] Newsletter glucoprotamin from the manufacturer Ecolab from February 2016 (pdf, 0.84 MB)

[2] Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of glutamic acid, reaction products with N- (C _12-14 -alkyl) propylenediamine in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on November 16, 2019, is reproduced from a self-classification by the distributor .

[CLP_100.100.563-3] Entry on glutamic acid, reaction products with N- (C _12-14 -alkyl) propylenediamine in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on November 16, 2019. Manufacturers or distributors can expand the harmonized classification and labeling .

[4] Website of the Federal Institute for Occupational Safety and Health (accessed on September 15, 2019).

[5] DPMA - register number: 2006107 , accessed on October 4, 2019.

[6] Steber J., Schröder FR: Glucoprotamin® - an antimicrobial agent with favorable degradation properties. Hyg Med 1996; 22: 19-26.

[7] B. Meyer, C. Kluin: Efficacy of Glucoprotamin® containing disinfectants against different species of atypical mycobacteria. In: J Hosp Infect. 42, 1999, pp. 151-154.

[8] Website of the German Patent and Trademark Office (accessed on May 24, 2020).

[9] PDF on the reprocessing of vaginal probes on the website of the Robert Koch Institute (accessed on September 19, 2019).