HBZ (protein)

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HBZ (protein)
HBZ (protein)
Structure of the HBZ protein
Identifier
Gene name (s) HBZ
External IDs

The subunit hemoglobin zeta is a protein encoded by the HBZ gene present in humans.

The zeta-globin is a hemoglobin similar to the alpha-globin . The zeta-globin polypeptide is synthesized in the yolk sac of an early embryo , while the alpha-globin is produced throughout the life of a fetus as well as an adult. The zeta-globin gene is a member of the human alpha-globin gene cluster , which contains five functional genes and two pseudogenes . The order of the genes is: 5 '- zeta - pseudozeta - my - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.

Individual evidence

  1. Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ: A review of the molecular genetics of the human alpha-globin gene cluster . In: Blood . 73, No. 5, May 1989, pp. 1081-104. PMID 2649166 .
  2. a b Entrez Gene: HBZ hemoglobin, zeta . Retrieved May 19, 2012.

literature

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  • Proudfoot NJ, Brownlee GG: 3 'non-coding region sequences in eukaryotic messenger RNA . In: Nature . 263, No. 5574, 1976, pp. 211-4. doi : 10.1038 / 263211a0 . PMID 822353 .
  • Fougerousse F, Meloni R, Roudaut C, Beckmann JS: Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1) . In: Nucleic Acids Res . 20, No. 5, 1992, p. 1165. doi : 10.1093 / nar / 20.5.1165 . PMID 1549498 . PMC 312136 (free full text).
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  • CA Marotta, BG Forget, SM Weissman, IM Verma, RP McCaffrey, D. Baltimore: Nucleotide Sequences of Human Globin Messenger RNA . In: Proc. Natl. Acad. Sci. USA . 71, No. 6, 1974, pp. 2300-4. doi : 10.1073 / pnas.71.6.2300 . PMID 4135409 . PMC 388440 (free full text).
  • Perez-Stable C, Ayres TM, Shen CK: Distinctive sequence organization and functional programming of an Alu repeat promoter . In: Proc. Natl. Acad. Sci. USA . 81, No. 17, 1984, pp. 5291-5. doi : 10.1073 / pnas.81.17.5291 . PMID 6089189 . PMC 391689 (free full text).
  • Clegg JB, Gagnon J: Structure of the zeta chain of human embryonic hemoglobin . In: Proc. Natl. Acad. Sci. USA . 78, No. 10, 1982, pp. 6076-80. doi : 10.1073 / pnas.78.10.6076 . PMID 6171809 . PMC 348980 (free full text).
  • Aschauer H, Schäfer W, Sanguansermsri T, Braunitzer G: [Human embryonic haemoglobins. Ac-Ser-Leu-Thr-is the N-terminal sequence of the zeta-chains (author's transl)] . In: Hoppe-Seyler's Z. Physiol. Chem. . 362, No. 12, 1982, pp. 1657-9. PMID 6172357 .
  • Aschauer H, Sanguansermsri T, Braunitzer G: [Human embryonic haemoglobins. The primary structure of the zeta chains (author's transl)] . In: Hoppe-Seyler's Z. Physiol. Chem. . 362, No. 8, 1982, pp. 1159-62. PMID 6179844 .
  • Proudfoot NJ, Gil A, Maniatis T : The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene . In: Cell . 31, No. 3 Pt 2, 1983, pp. 553-63. doi : 10.1016 / 0092-8674 (82) 90311-7 . PMID 6297773 .
  • Goodbourn SE, Higgs DR, Clegg JB, Weatherall DJ: Molecular basis of length polymorphism in the human zeta-globin gene complex . In: Proc. Natl. Acad. Sci. USA . 80, No. 16, 1983, pp. 5022-6. doi : 10.1073 / pnas.80.16.5022 . PMID 6308667 . PMC 384180 (free full text).
  • MM Cohen-Solal, B. Authier, JK deRiel, MJ Murnane, BG Forget: Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA . In: DNA . 1, No. 4, 1983, pp. 355-63. doi : 10.1089 / dna.1982.1.355 . PMID 6963223 .
  • Orkin SH, Michelson A: Partial deletion of the alpha-globin structural gene in human alpha-thalassemia . In: Nature . 286, No. 5772, 1980, pp. 538-40. doi : 10.1038 / 286538a0 . PMID 7402334 .
  • J. Flint, K. Thomas, G. Micklem, H. Raynham, K. Clark, NA Doggett, A. King, DR Higgs: The relationship between chromosome structure and function at a human telomeric region . In: Nat. Genet. . 15, No. 3, 1997, pp. 252-7. doi : 10.1038 / ng0397-252 . PMID 9054936 .
  • HY Luo, XL Liang, C. Frye, M. Wonio, GD Hankins, DH Chui, BP Age: Embryonic hemoglobins are expressed in definitive cells . In: Blood . 94, No. 1, 1999, pp. 359-61. PMID 10381533 .
  • RJ Daniels, JF Peden, C. Lloyd, SW Horsley, K. Clark, C. Tufarelli, L. Kearney, VJ Buckle, NA Doggett, J. Flint, DR Higgs: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 . In: Hum. Mol. Genet. . 10, No. 4, 2001, pp. 339-52. doi : 10.1093 / hmg / 10.4.339 . PMID 11157797 .
  • ET Lau, YK Kwok, DH Chui, HS Wong, HY Luo, MH Tang: Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures . In: Prenat. Diagn . 21, No. 7, 2001, pp. 529-39. doi : 10.1002 / pd.81 . PMID 11494285 .