Hemoglobin theta-1
| Hemoglobin theta-1 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 141 amino acids | |
| Cofactor | Hamm | |
| Identifier | ||
| Gene name | HBQ1 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Mammals | |
Hemoglobin theta-1 is a protein found in mammals that functions as an oxygen transporter in the blood . It is part of hemoglobin - tetramer which in large quantities of, erythrocytes are produced. In particular, theta globin is only formed in humans during embryonic development. Theta globin is one of the globins .
The theta-globin mRNA is found in human, fetal , erythroid tissue, but not in erythroid or other non-erythroid tissues of adults. The theta-1 genes manifest themselves very early in embryonic life, sometimes maybe even before the fifth week. Theta-1 is a member of the human alpha globin gene cluster , which contains five functional genes and two pseudogenes . The order of the genes is: 5 '- zeta - pseudozeta - my - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'. Research suggests a transcriptionally active role for the gene and a functional role for peptides in specific cells, possibly in those of early erythroid tissue.
Individual evidence
- ↑ Orthologist at OMA
- ↑ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ: A review of the molecular genetics of the human alpha-globin gene cluster . In: Blood . 73, No. 5, May 1989, pp. 1081-104. PMID 2649166 .
- ↑ a b Entrez Gene: HBQ1 hemoglobin, theta 1 . Retrieved May 20, 2012.
literature
- Giardina B, Messana I, Scatena R, Castagnola M: The multiple functions of hemoglobin. . In: Crit. Rev. Biochem. Mol. Biol . 30, No. 3, 1995, pp. 165-96. doi : 10.3109 / 10409239509085142 . PMID 7555018 .
- Kim JH, Yu CY, Bailey A, et al. : Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters. . In: Nucleic Acids Res . 17, No. 14, 1989, pp. 5687-700. doi : 10.1093 / nar / 17.14.5687 . PMID 2569721 . PMC 318189 (free full text).
- Ley TJ, Maloney KA, Gordon JI, Schwartz AL: Globin gene expression in erythroid human fetal liver cells. . In: J. Clin. Invest. . 83, No. 3, 1989, pp. 1032-8. doi : 10.1172 / JCI113944 . PMID 2921315 . PMC 303780 (free full text).
- Gonzalez-Redondo JM, Han IS, Gu YC, Huisman TH: Nucleotide sequence of the human theta 1-globin gene. . In: Biochem. Genet. . 26, No. 3-4, 1988, pp. 207-11. doi : 10.1007 / BF00561460 . PMID 3408475 .
- Hsu SL, Marks J, Shaw JP, et al. : Structure and expression of the human theta 1 globin gene . In: Nature . 331, No. 6151, 1988, pp. 94-6. doi : 10.1038 / 331094a0 . PMID 3422341 .
- Daniels RJ, Peden JF, Lloyd C, et al. : Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 . In: Hum. Mol. Genet. . 10, No. 4, 2001, pp. 339-52. doi : 10.1093 / hmg / 10.4.339 . PMID 11157797 .
- Strausberg RL, Feingold EA, Grouse LH, et al. : Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . In: Proc. Natl. Acad. Sci. USA . 99, No. 26, 2003, pp. 16899-903. doi : 10.1073 / pnas.242603899 . PMID 12477932 . PMC 139241 (free full text).
- Gerhard DS, Wagner L, Feingold EA, et al. : The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . In: Genome Res. . 14, No. 10B, 2004, pp. 2121-7. doi : 10.1101 / gr.2596504 . PMID 15489334 . PMC 528928 (free full text).
- De Gobbi M, Viprakasit V, Hughes JR, et al. : A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter . In: Science . 312, No. 5777, 2006, pp. 1215-7. doi : 10.1126 / science.1126431 . PMID 16728641 .