Hans-Beat Hadorn

Hans-Beat Hadorn (born May 13, 1933 in Oberdiessbach ) is a Swiss pediatrician and former university professor.

Life

Hans-Beat Hadorn, son of developmental biologist and geneticist Ernst Hadorn (1902–1976), studied medicine at the University of Zurich, received his doctorate in 1961 with a thesis on biochemical genetics in galactosemia , worked as Franz Leuthardt's assistant in the biochemical institute, then with Andrea Prader at the Children's Clinic of the University of Zurich. Hadorn also completed a vocal degree in Zurich (with Heinz Rehfuss and later with Brigitte Kuhn-Indermühle).

He spent 1966/1967 on a scholarship from the Swiss Academy of Medical Sciences at the Royal Children's Hospital Melbourne under Charlotte M. Anderson, where he obtained a Doctor of Philosophy (PhD) for a biochemical thesis on the activation of trypsinogen by human enterokinase . In 1968 he worked at the Institut d'embryologie expérimentale at the Collège de France in Paris under the direction of Etienne Wolff and Françoise Dieterlen .

After his habilitation in pediatrics , he was appointed associate professor for pediatrics at the University of Bern in 1971 and was head of the department for pediatric gastroenterology at the University Children's Hospital in Bern with Ettore Rossi . In 1978 he was appointed to the chair of paediatrics at the University of Graz and was appointed director of the children's clinic. In 1983 he was appointed full professor of paediatrics and director of the children's clinic at the Ludwig Maximilians University in Munich , the Dr. von Hauner's Children's Hospital .

After his retirement in 1998, he continued to work in various areas of clinical research on the pathophysiology of cystic fibrosis and taught biology and chemistry at a private school south of Munich for five years. He is also active as a choir singer, vocal soloist and illustrator. Hadorn has been an honorary member of MünchenKlang eV since May 2016. He is married for the second time and has a daughter from this marriage. A son and a daughter are from the previous marriage.

Research and Teaching

Hadorn's research focus is pediatric gastroenterology. During his stay in Melbourne he discovered an unknown congenital enzyme defect , the lack of intestinal enteropeptidase (formerly called enterokinase). At the Haunersche Children's Hospital, “Beat Hadorn's term of office (1984–1998)… in the scientific field was characterized by new requirements and opportunities as a result of the rapid development of molecular genetics and analytical laboratory methods. ... The analysis of mutations, the cloning of new genes and the identification of disease genes have become important topics in many subspecialties. Interdisciplinary molecular medicine was the determining main topic in research and the subject of many publications of the time. Occasionally with lasting practical effects: The comprehensive, extended newborn screening in Germany was further developed in the late 1990s from a project of the clinic in the National Genome Research Network (NGFN), based on new process developments, until it was ready for use. "

In 2002, Hadorn and Andreas Holzinger were able to detect several gene mutations in families of patients with enteropeptidase deficiency that are responsible for the loss of activity of the enzyme. His discovery of the defect in bicarbonate secretion in cystic fibrosis has triggered numerous works, including from the field of basic science, and given rise to a paradigm shift in the area of the concepts that are used to explain the manifold disorders of exocrine glands in cystic fibrosis.

In addition, since his work in Bern, Hadorn has repeatedly advocated the reform of medical studies in the sense of intensifying practical teaching at the bedside. Beat Hadorn received the First Prize of the Swiss Society for Gastroenterology in 1970. He is a member of various national and international societies for pediatrics, including the European Society for Pediatric Gastroenterology and Hepatology (founding member), the European Society for Pediatric Research, the European Working Group for Cystic Fibrosis , EWGCF (first secretary) and a corresponding member of the Société Française de Pediatrie .

social commitment

The social commitment runs through the entire life of Hadorn. As a participant in the summer night musical for charity and as a member of the Refudocs , which take care of medical care for arriving refugees in Munich, he last appeared in public in Munich.

Fonts

with MJ Tarlow, JK Lloyd, OH Wolff: Intestinal Enterokinase Deficiency. In: The Lancet , 1959, 1 (7599) pp. 812-813.
with PG Johansen and CM Anderson: Pancreozymin-Secretin Test of Exocrine Pancreatic Function in Cystic Fibrosis and the Significance of the Result for the Pathogenesis of the Disease. In: Canadian Medical Asiocation Journal , Feb. 1968, No. 98, pp. 377-385. PMC 1923879 (free full text)
with JR Green, EE Stechi, HP Hauri: Biochemical Mechanisms in Congenital Enzyme Deficiencies of the Small Intestine. In: Clinics in Gastroenterology (1981) 10.3, pp. 671-690.
with Andreas Holzinger, Esther M. Maier, Cornelius Bück, Peter U. Mayerhofer, Matthias Kappler, James C. Haworth, Stanley P. Moroz, JE Sadler, AA Roscher: Mutations in the Proenteropeptidase Gene are the Molecular Cause of Congenital Enteropeptidase Deficiency. in: The American Journal of Human Genetics , 2002, 70: pp. 20-25. doi : 10.1086 / 338456
Michael Studer : Aunt Amalie. With illustrations by Beat Hadorn. Weber, Thun 2009, ISBN 978-3-909532-57-5 .

literature

Hadorn, Hans Beat. In: The lecturers of the Bern University of Applied Sciences 1528–1984. University of Bern, Bern 1984, 4.2.070.

Individual evidence

↑ Honorary Members. In: Website of MünchenKlang. Retrieved May 11, 2016 .
↑ Orientation of research to subspecialties and special laboratories. Website of the Klinikum der Universität München (MU), accessed on April 8, 2015.
^ Karl Kunzelmann, Rainer Schreiber, Hans Beat Hadorn: Bicarbonate in cystic fibrosis . In: Journal of Cystic Fibrosis . No. 16 , 2017, p. 653-662 .
↑ Team - Actor. Retrieved February 27, 2017 .
↑ Abendzeitung, Germany: Refudocs in the Bayernkaserne: Asylum seekers: Medical Association takes care of refugees - Abendzeitung Munich . ( Abendzeitung-muenchen.de [accessed on February 27, 2017]).

personal data
SURNAME	Hadorn, Hans-Beat
ALTERNATIVE NAMES	Hadorn, beat
BRIEF DESCRIPTION	Swiss pediatrician
DATE OF BIRTH	May 13, 1933
PLACE OF BIRTH	Oberdiessbach

[1] Honorary Members. In: Website of MünchenKlang. Retrieved May 11, 2016 .

[2] Orientation of research to subspecialties and special laboratories. Website of the Klinikum der Universität München (MU), accessed on April 8, 2015.

[3] Karl Kunzelmann, Rainer Schreiber, Hans Beat Hadorn: Bicarbonate in cystic fibrosis . In: Journal of Cystic Fibrosis . No. 16 , 2017, p. 653-662 .

[4] Team - Actor. Retrieved February 27, 2017 .

[5] Abendzeitung, Germany: Refudocs in the Bayernkaserne: Asylum seekers: Medical Association takes care of refugees - Abendzeitung Munich . ( Abendzeitung-muenchen.de [accessed on February 27, 2017]).