Hans-Gert Bernstein

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Hans-Gert Bernstein (born July 15, 1950 in Leipzig ) is a German neurobiologist.

Hans-Gert Bernstein private 2.jpg

Professional background

Hans-Gert Bernstein grew up in Böhlitz-Ehrenberg (today part of Leipzig). After graduating from ABF II Halle in 1969 , he studied biology at the Faculty of Biology and Soil Science at Lomonossow University in Moscow . In 1974 Hans-Gert Bernstein took up an aspirational position at the Biosciences Section of the Karl Marx University in Leipzig , where he received his doctorate in 1978 on the subject of "Thiamine pyrophosphatase and 5'-nucleotidase in the rat hippocampus". In 1982 he completed his habilitation at the Institute for Anatomy and Biology of the Medical Academy Magdeburg on the subject of "Cerebral immunoreactive insulin". From 1987 Hans-Gert Bernstein worked as a lecturer in anatomy. In 1989 he took over a position as head of department for neuromorphology at the Leibniz Institute for Neurobiology Magdeburg (LIN). In 1996 Hans-Gert Bernstein was appointed adjunct professor for psychiatry at the medical faculty of Otto von Guericke University Magdeburg . As head of the laboratory for experimental psychiatry, he researched the neuropathology of schizophrenia , depression and Alzheimer's disease .

Scientific work

Hans-Gert Bernstein deals with the pathophysiological causes of neuropsychiatric diseases. The focus is on the immunohistochemical examination of brain tissue. Research into cathepsins , insulin metabolism in the brain, neurotransmitter disorders and neuro- inflammation play an important role here.

His scientific findings to date have resulted in around 300 publications. Together with Alfred Dorn he published the book Laborpraxis in der Immunhistochemie. Jena, 1983 ISBN 3-437-10882-4

Publications

  • The hypothalamus and neuropsychiatric disorders: psychiatry meets microscopy. Bernstein HG, Dobrowolny H, Bogerts B, Keilhoff G, Steiner. J.Cell Tissue Res. 2019 Jan; 375 (1).
  • Putative roles of cathepsin B in Alzheimer's disease pathology: The good, the bad, and the ugly in one? Bernstein HG, Keilhoff G. Neural Regen Res. 2018 Dec; 13 (12).
  • Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy. Bernstein HG, Steiner J, Bogerts B. Expert Rev Neurother. 2009 Jul; 9 (7).
  • Repeated application of ketamine to rats induces changes in the hippocampal expression of parvalbumin, neuronal nitric oxide synthase and cFOS similar to those found in human schizophrenia. Keilhoff G, Becker A, Grecksch G, Wolf G, Bernstein HG. Neuroscience. 2004; 126 (3)
  • Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques. Bernstein HG, Ansorge S, Riederer P, Reiser M, Frölich L, Bogerts B. Neurosci Lett. 1999 Mar 26; 263 (2-3)
  • Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Bernstein HG, Stanarius A, Baumann B, Henning H, Krell D, Danos P, Falkai P, Bogerts B. Neuroscience. 1998 Apr; 83 (3)

Awards

  • In 1983 he received the Johannes Müller Medal for his habilitation thesis
  • In 2000 he received the Schönwald Prize for his Alzheimer's research

Memberships

Individual evidence

  1. ↑ Bernstein HG - Search Results. Retrieved June 22, 2020 (English).
personal data
SURNAME Bernstein, Hans-Gert
BRIEF DESCRIPTION German neurobiologist
DATE OF BIRTH July 15, 1950
PLACE OF BIRTH Leipzig