Hexamidine

from Wikipedia, the free encyclopedia
Structural formula
Structural formula of hexamidine
General
Surname Hexamidine
other names

4,4 '- [1,6-hexanediylbis (oxy)] dibenzenecarboximidamide

Molecular formula C 20 H 26 N 4 O 2
Brief description

white odorless solid

External identifiers / databases
CAS number
  • 3811-75-4
  • 659-40-5 (diisethionate)
  • 50357-46-5 (dihydrochloride)
PubChem 65130
ChemSpider 58639
DrugBank DB03808
Wikidata Q250360
Drug information
ATC code

S01 AX08

properties
Molar mass 354.45 g mol −1
Physical state

firmly

Melting point

246–247 ° C (diisethionate, decomposition)

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 302
P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Hexamidine is a chemical compound from the group of dibenzamidines .

use

Hexamidine and its diisethionate are used as antibacterial agents or as disinfectants and preservatives, for example in cosmetics. It is also used in ophthalmology, for example to treat Acanthamoeba keratitis, in the form of eye drops. Hexamidine was patented by May & Baker in 1939 and is commercially available as a generic .

safety instructions

Hexamidine diisethionate can cause allergic skin reactions.

Individual evidence

  1. ^ Wilfried Paulus: Directory of Microbicides for the Protection of Materials A Handbook . Springer Science & Business Media, 2005, ISBN 978-1-4020-2817-5 ( limited preview in Google book search).
  2. ↑ a b Franz v. Bruchhausen, G. Dannhardt, Siegfried Ebel, August Wilhelm Frahm, Eberhard Hackenthal, Ulrike Holzgrabe: Hager's Handbook of Pharmaceutical Practice Volume 8: Substances EO . Springer-Verlag, 2013, ISBN 978-3-642-57994-3 , pp. 431 ( limited preview in Google Book search).
  3. ↑ a b Datasheet Hexamidine diisethionate, European Pharmacopoeia (EP) Reference Standard from Sigma-Aldrich , accessed on January 31, 2016 ( PDF ).
  4. ↑ unknown: Final Report on the Safety Assessment of Hexamidin and Hexamidin Diisethionate. In: International Journal of Toxicology. 26, 2007, p. 79, doi : 10.1080 / 10915810701663168 .
  5. ^ A b Jean-Pierre Lepoittevin, Christophe J. Coz: Dictionary of Contact Allergens . Springer Science & Business Media, 2007, ISBN 978-3-540-74165-7 , pp. 137 ( limited preview in Google Book search).
  6. ^ Carl Erb, Torsten Schlote: drug eye therapy . Georg Thieme Verlag, 2010, ISBN 978-3-13-160045-5 , p. 474 ( limited preview in Google Book search).
  7. ^ Acanthamoeba Keratitis Treatment. April 1, 2006, accessed March 2, 2020 .
  8. ↑ Entry on hexamidine. In: Römpp Online . Georg Thieme Verlag, accessed on January 31, 2016.