Histone deacetylase 4
| Histone deacetylase 4 | ||
|---|---|---|
|
||
| according to PDB 2vqj | ||
| other names |
Histone Deacetylase A |
|
|
Existing structural data : 2H8N , 2O94 , 2VQJ , 2VQM , 2VQO , 2VQQ |
||
| Properties of human protein | ||
| Mass / length primary structure | 1084 amino acids, 119040 Da | |
| Identifier | ||
| Gene names | HDAC4 HDACA; AHO3; BDMR; HD4; KIAA0288 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.5.1.98 | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 9759 | 208727 |
| Ensemble | ENSG00000068024 | ENSMUSG00000026313 |
| UniProt | P56524 | Q6NZM9 |
| Refseq (mRNA) | NM_006037 | NM_207225 |
| Refseq (protein) | NP_006028 | NP_997108 |
| Gene locus | Chr 2: 239.05 - 239.4 Mb | Chr 1: 91.93 - 92.18 Mb |
| PubMed search | 9759 |
208727
|
The histone deacetylase 4 (HDAC 4) is an enzyme , the acetylation of histones removed and thus, inter alia, on the condensation of the chromatin and to the differentiation is involved by certain cells.
properties
The HDAC4 in turn can be modified by phosphorylation , sumoylation , carbonylation, ubiquitination and proteolysis . HDAC 4 is a class II histone deacetylase (HDAC / acuc / apha family). HDAC 4 is recruited close to the DNA by binding to the transcription factors MEF2C and MEF2D . HDAC binds to the protein complex of RbAp48 and HDAC3 . HDAC4 is necessary for the differentiation of myofibroblasts by TGFbeta1 . HDAC 4 is involved in the development of muscles and bones .
literature
- Jeremy M. Berg, John L. Tymoczko, Lubert Stryer : Biochemistry. 6 edition, Spektrum Akademischer Verlag, Heidelberg 2007. ISBN 978-3-8274-1800-5 .
- Donald Voet, Judith G. Voet: Biochemistry. 3rd edition, John Wiley & Sons, New York 2004. ISBN 0-471-19350-X .
- Bruce Alberts , Alexander Johnson, Peter Walter, Julian Lewis, Martin Raff, Keith Roberts: Molecular Biology of the Cell , 5th Edition, Taylor & Francis 2007, ISBN 978-0-8153-4106-2 .
Individual evidence
- ↑ Zhengke Wang, Gangjian Qin, Ting C Zhao: HDAC4: mechanism of regulation and biological functions. In: Epigenomics. 6, 2014, p. 139, doi : 10.2217 / epi.13.73 . PMID 24579951 . PMC 4380265 (free full text).
- ↑ Entrez Gene: HDAC4 histone deacetylase 4 .
- ↑ Glenisson W, Castronovo V, Waltregny D: Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation. . In: Biochim Biophys Acta. . 1773, No. 10, October 2007, pp. 1572-82. doi : 10.1016 / j.bbamcr.2007.05.016 . PMID 17610967 .