Hyperthecosis ovarii

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Classification according to ICD-10
E28.8 Other ovarian dysfunction
ICD-10 online (WHO version 2019)

The Hyperthecosis ovarii denotes a familial occurring closely with PCOS related disease with hyperplasia of theca cells with the main features of virilization , hirsutism and infertility .

Synonyms are: hyperthecosis; Thecomatosis

The name was first used in 1971.

pathology

Histologically, there is hyperplasia of the theca cells in atretic ovarian follicles , an overall decreased number of follicles and an increase in stromal tissue . The plasma levels of dihydrotestosterone , testosterone and luteinizing hormone (LH) are increased, those of estradiol and follicle-stimulating hormone (FSH) are decreased.

Some male family members have been found to have low testosterone and elevated LH and FSH levels.

A presumably autosomal dominant inheritance is assumed.

In contrast to PCOS, there are no polycystic changes.

Clinical manifestations

Clinical criteria are:

In addition, there is often acanthosis nigricans .

diagnosis

In addition to the findings of the clinical examination , the results of laboratory medicine are decisive; medical imaging can document the enlargement of the ovaries, which is usually present on both sides, and is also of limited value.

Differential diagnosis

A distinction must be made between PCOS and a fibroma of the ovary.

literature

  • AL Castell, S. Hieronimus, A. Chevallier, JL Sadoul, MB Galand-Portier, J. Delotte, P. Fénichel: Hyperthécose ovarienne post-ménopausique. In: Gynécologie Obstétrique & Fertilité. Vol. 40, No. 5, May 2012, pp. 316-319, doi: 10.1016 / j.gyobfe.2011.07.049 , PMID 22336524 .
  • JH Barth, M. Jenkins, PE Belchetz: Ovarian hyperthecosis, diabetes and hirsuties in post-menopausal women. In: Clinical endocrinology. Vol. 46, No. 2, February 1997, pp. 123-128, PMID 9135690 .
  • U. Schwartz, L. Moltz et al. a .: Hyperthecosis ovarii - a tumor-like change in androgenized women *. In: Obstetrics and gynecology. 46, 1986, p. 391, doi: 10.1055 / s-2008-1035937 .

Individual evidence

  1. ↑ a b Willibald Pschyrembel : Clinical Dictionary , 266th, updated edition, de Gruyter, Berlin 2014, ISBN 978-3-11-033997-0
  2. ↑ a b c Entry on Hyperthecosis ovarii in the Flexikon , a Wiki of the DocCheck company
  3. ↑ JR Givens, WL Wiser, SA Coleman et al .: Familial ovarian hyperthecosis: a study of two families. In: American Journal of Obstetrics & Gynecology, Vol. 110, 1971, pp. 959-972
  4. ↑ a b Radiopaedia
  5. ↑ AB Rosenkrantz, D. Popiolek, GL Bennett, EM Hecht: Magnetic resonance imaging appearance of ovarian stromal hyperplasia and ovarian hyperthecosis. In: Journal of computer assisted tomography. Vol. 33, No. 6, 2009 Nov-Dec, pp. 912-916, doi: 10.1097 / RCT.0b013e3181a2ec0c , PMID 19940659 .
  6. ↑ P. Rousset, D. Vadrot, JN Buy: What is the role of sonography in the diagnosis of ovarian hyperthecosis? In: Journal of ultrasound in medicine: official journal of the American Institute of Ultrasound in Medicine. Vol. 28, No. 8, August 2009, p. 1123; author reply 1124, PMID 19643801 .