Iodophthalein

Structural formula
General
Non-proprietary name	Iodophthalein
other names	3 ', 3' ', 5', 5 '' - tetraiodophenolphthalein; 3,3-bis (4-hydroxy-3,5-diiodophenyl) -3 H -isobenzofuran-1-one ( IUPAC ); Nosophs;
Molecular formula	C 20 H 10 I 4 O 4
External identifiers / databases
ECHA InfoCard	100.006.235
PubChem	67846
Wikidata	Q19286247
properties
Molar mass	821.91 g · mol -1
solubility	Practically insoluble in water; sparingly soluble in ethanol ; soluble in alkalis , chloroform , diethyl ether
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Iodophthalein (tetraiodophenolphthalein, nosophen) is a medicinal substance . It is formed by the action of iodine on phenolphthalein and forms a yellow-white, odorless and tasteless powder that is insoluble in water and acids, soluble in ether and chloroform and melts at 225 ° C with decomposition.

It was previously used because of its non-toxicity and strong antiseptic effect, mostly as a dry powder, for wound treatment, especially in the case of extensive burns, ulcers, etc., and was also considered suitable for the treatment of syphilis .

The disodium salt of iodophthalein (antinosine) is a blue, water-soluble powder and was also used as a wound remedy, but also for the treatment of intestinal catarrh . The solution was shown to be effective against anthrax , diphtheria and pus bacteria .

Iodophthalein and iodophthalein disodium salt are among the x - ray contrast media containing iodine .

Nowadays more modern drugs are used instead of iodophthalein and its salts.

Individual evidence

↑ Merck Index 13th Ed.
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ ^a ^b ^c ^d Nosophen. In: Meyers Konversations-Lexikon. 4th edition. Volume 14, Verlag des Bibliographisches Institut, Leipzig and Vienna 1885–1892, p. 809.
^ W. Franklin Coleman (1898): Antinosin in the Treatment of Diseases of the Eye and Ear . In: JAMA , 30: 256-257.

[1] Merck Index 13th Ed.

[NV-2] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[MGKL-3] Nosophen. In: Meyers Konversations-Lexikon. 4th edition. Volume 14, Verlag des Bibliographisches Institut, Leipzig and Vienna 1885–1892, p. 809.

[4] W. Franklin Coleman (1898): Antinosin in the Treatment of Diseases of the Eye and Ear . In: JAMA , 30: 256-257.