Isocarboxazid

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Structural formula
Structural formula of isocarboxazid
General
Non-proprietary name Isocarboxazid
other names

N ′ -Benzyl-5-methylisoxazole-3-carbohydrazide ( IUPAC )

Molecular formula C 12 H 13 N 3 O 2
External identifiers / databases
CAS number 59-63-2
EC number 200-438-4
ECHA InfoCard 100,000,399
PubChem 3759
ChemSpider 3628
DrugBank DB01247
Wikidata Q409595
Drug information
ATC code

N06 AF01

Drug class

Antidepressants

Mechanism of action

MAOIs

properties
Molar mass 231.25 g mol −1
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
06 - Toxic or very toxic

danger

H and P phrases H: 301
P: ?
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Isocarboxazid is an irreversible, non-selective inhibitor of monoamine oxidase ( MAO inhibitor ) from the group of hydrazines , which is used as an antidepressant and anxiolytic . Along with phenelzine , it is one of the few hydrazine-based MAO inhibitors still in use.

Isocarboxazid is used to combat various health disorders, such as depression , social phobia or panic disorders, and is now also used to support the fight against Parkinson's disease and other dementia-related disorders. Although isocarboxazid is a helpful drug , it has numerous side effects.

Side effects

Side effects of isocarboxazid include:

Others

Isocarboxazid is not the drug of choice for depression and anxiety disorder because it interacts with various foods that contain tyramine . It inhibits the breakdown of this biogenic amine, which is contained in everyday foods, which, among other things, can lead to severe blood pressure crises. As a result, isocarboxazid and other MAOIs are often considered the last resort for depression.

literature

  • Fiedorowicz JG, Swartz KL: The role of monoamine oxidase inhibitors in current psychiatric practice . In: Journal of Psychiatric Practice . 10, No. 4, July 2004, pp. 239-248. PMID 15552546 . PMC 2075358 (free full text).

Individual evidence

  1. ↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of isocarboxazid in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), which was accessed on February 11, 2020, is reproduced from a self-classification by the distributor .
  2. ↑ Fagervall I, Ross SB: Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors . In: Biochemical pharmacology . 35, No. 8, April 1986, pp. 1381-7. doi : 10.1016 / 0006-2952 (86) 90285-6 . PMID 2870717 .
  3. ↑ Volz, Hanz-Peter. (November 1998) “Monoamine Oxidase Inhibitors A Perspective on Their Use in The Elderly” Biochemical pharmacology (5) 341-352.