Jan Korbel

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Jan Oliver Korbel (born February 15, 1975 in Chêne-Bougeries ) is a Swiss-born German natural scientist who works in molecular biology , human genetics and bioinformatics .

Life

Korbel grew up in Switzerland and northern Germany and studied at the Technical University of Berlin and the Humboldt University of Berlin . Following his doctoral thesis in 2005 at EMBL and at the Humboldt University in Berlin, he conducted research at Yale University , New Haven (Connecticut) in the USA from 2005–2007 . Korbel has been a group leader since 2008, a full-time senior scientist since 2016, and head of data science at the European Molecular Biology Laboratory (EMBL) in Heidelberg since 2020 . In addition to Matthias Hentze and Andreas Kulozik, he is one of the co-directors of the Molecular Medicine Partnership Unit (MMPU) at EMBL and the Medical Faculty of Heidelberg University .

The scientific objective of his work is to understand genetic variants (i.e. genetic variation ) as the cause of phenotypic differences and the development of cancer . Korbel's research focuses on the so-called structural variations of the genome (in particular deletions , duplications , inversions , translocations and more complex genetic rearrangements such as chromothripsis ), as well as on concepts for the joint (integrative) analysis of different data forms ( transcriptomes , data from individual cells , health data ) to research biological processes of disease development. He has developed methods to structural variations in the genome by DNA sequencing in high throughput as well as by single cell analysis to identify.

In addition to his scientific activities, Korbel is involved in interdisciplinary discussions in bioethics on the application of genetic sequencing in biomedicine . Korbel has received several science awards, including the Chica and Heinz Schaller Science Prize (2014), the Manfred Fuchs Prize for Bioethical Work (2015), the HMLS Prize (2018) and the Pezcoller Foundation awarded by the European Association for Cancer Research -EACR Cancer Research Award (2018). The scientific working group of Korbel is the European Research Council funded (European Research Council). Korbel has been a member of the European Molecular Biology Organization since 2016 . On June 23, 2015 Jan Korbel was registered under matriculation no. 7653 in the section Human Genetics and Molecular Medicine as a member of the National Academy of Sciences Leopoldina .

Publications

Web links

Individual evidence

  1. ↑ Korbel Group - Members - EMBL. Retrieved September 28, 2019 .
  2. ^ Molecular Medicine Partnership Unit - EMBL. Retrieved September 28, 2019 .
  3. ^ Korbel Group - From genomic variation to molecular mechanism - EMBL. Retrieved September 28, 2019 .
  4. ↑ JO Korbel et al. : Paired-end mapping reveals extensive structural variation in the human genome. In: Science Volume 318, September 2007, pp. 420-426, doi : 10.1126 / science.1149504 PMID 17901297 .
  5. ↑ T. Rausch, T. Zichner, A. Schlattl, AM Stütz, V. Benes, JO Korbel: DELLY: structural variant discovery by integrated paired-end and split-read analysis. In: Bioinformatics Volume 28, September 2012, pp. I333-i339, doi : 10.1093 / bioinformatics / bts378 PMID 22962449 .
  6. ↑ A. Sanders, S. Meiers, M. Ghareghani, D. Porubsky, H. Jeong, MA van Vliet, T. Rausch, P. Richter-Pechańska, J. Kunz, S. Jenni, D. Bolognini, G. Longo , B. Raeder, V. Kinanen, J. Zimmermann, V. Benes, M. Schrappe, B. Mardin, A. Kulozik, B. Bornhauser, J. Bourquin, T. Marschall, JO Korbel: Single-cell analysis of structural variations and complex rearrangements with tri-channel processing. In: Nat Biotechnol , 2019 PMID 31873213
  7. ↑ EURAT - Ethical and Legal Aspects of Total Sequencing of the Human Genome - Heidelberg University. Retrieved September 28, 2019 .
  8. ↑ Awards Made. Retrieved September 28, 2019 .
  9. ^ Manfred Fuchs Prize. Retrieved September 28, 2019 .
  10. ↑ Jan Korbel And Stefan Pfister Received HMLS Investigator Award. Retrieved September 28, 2019 .
  11. ↑ Previous winners of the Pezcoller Foundation - EACR Cancer Researcher Award | EACR - European Association for Cancer Research. Retrieved September 28, 2019 .
  12. ^ ERC Investigators - EMBL. Retrieved September 28, 2019 .
  13. ↑ EMBO members. Retrieved September 28, 2019 (UK English).
personal data
SURNAME Korbel, Jan
ALTERNATIVE NAMES Korbel, Jan Oliver (full name)
BRIEF DESCRIPTION Swiss natural scientist
DATE OF BIRTH 15th February 1975
PLACE OF BIRTH Chêne-Bougeries