Potassium toxin 1

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Potassium channel toxin alpha-KTx 3.1
other names

Kaliotoxin 1, KTx 1

Existing structure data : PDB  1KTX , PDB  1XSW , PDB  2KTX

Mass / length primary structure 38 amino acids , 4,156 Da
Identifier
External IDs

Kaliotoxin 1 (synonym Kaliumkanaltoxin alpha-KTx 3.5 ) is a toxin from the scorpion Androctonus australis .

properties

Kaliotoxin 1 is a protein and scorpion toxin from A. australis , as is potassium toxin 2 . It binds and inhibits voltage-gated potassium channels of the type Kv1.3 ( K d = 0.65 nM ), Kv1.6 . and Kv1.1 / KCNA1 (K d = 41 nM) and KCa1.1 / KCNMA1 ( Ki = 1560 nM), but not Kv1.2 / KCNA2 , Kv1.5 / KCNA5 and Kv3.1 / KCNC1 . Kaliotoxin 1 and 2 are structurally most closely related to Agitoxin 1 , Agitoxin 2, and Agitoxin 3 .

Web links

Individual evidence

  1. ^ A. Lange, K. Giller, S. Hornig, MF Martin-Eauclaire, O. Pongs, S. Becker, M. Baldus: Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR. In: Nature. Volume 440, number 7086, April 2006, pp. 959-962, doi : 10.1038 / nature04649 , PMID 16612389 .
  2. ↑ OV Nekrasova, AD Volyntseva, KS Kudryashova, VN Novoseletsky, EA Lyapina, AV Illarionova, SA Yakimov, YV Korolkova, KV Shaitan, MP Kirpichnikov, AV Feofanov: Complexes of Peptide Blockers with Kv1.6 Pore Domain: Molecular Modeling and Studies KcsA-Kv1.6 Channel. In: Journal of neuroimmune pharmacology: the official journal of the Society on NeuroImmune Pharmacology. Volume 12, Number 2, June 2017, pp. 260-276, doi : 10.1007 / s11481-016-9710-9 , PMID 27640211 .
  3. ^ Hervé Rochat: Animal Toxins. Springer Science & Business Media, 2000, ISBN 978-3-764-35983-6 , p. 184.