Bone Morphogenetic Protein 1

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Bone Morphogenetic Protein 1
Bone Morphogenetic Protein 1
according to 3EDG

Existing structural data : 3EDG , 3EDH

Properties of human protein
Mass / length primary structure 866 amino acids
Cofactor Zn 2+ , Ca 2+
Isoforms 7th
Identifier
Gene name BMP1
External IDs
Enzyme classification
EC, category 3.4.24.19 ,  metalloprotease
MEROPS M12.005
Response type Cleavage of peptide bonds
Substrate Ala - + - Asp / Arg - + - Asp in Procollagen-I / II / III and Pro-ApoA1
Products Collagen-I / II / III, ApoA1
Occurrence
Parent taxon multicellular animals
Orthologue
human House mouse
Entrez 649 12153
Ensemble ENSG00000168487 ENSMUSG00000022098
UniProt P13497 P98063
Refseq (mRNA) NM_001199 NM_009755
Refseq (protein) NP_001190 NP_033885
Gene locus Chr 8: 22.16 - 22.21 Mb Chr 14: 70.47 - 70.52 Mb
PubMed search 649 12153

Bone morphogenetic protein 1 (BMP1) is a protein whose homologues can be detected in all multicellular animals . In humans, BMP1 has on the one hand the function of a growth factor that can trigger the differentiation of mesenchymal cells into osteoblasts , on the other hand BMP1 has enzymatic activity: as a peptidase , it cleaves the precursors of collagens I, II and III as well as apolipoprotein A1 . It is therefore important for cartilage formation and reverse cholesterol transport . BMP1 is the only bone morphogenetic protein that does not belong to the TGF-beta superfamily ( transforming growth factor ) of cytokines . BMP1 belongs to the metalloproteases .

BMP1 inhibitors have shown the potential to be used in scar creams in cell and animal studies .

Individual evidence

  1. ↑ Homologues at OMA
  2. ↑ UniProt P13497
  3. ↑ H. Ibelgaufts / COPE: BMP
  4. ↑ Chau P, Fielding PE, Fielding CJ: Bone morphogenetic protein-1 (BMP-1) cleaves human proapolipoprotein A1 and regulates its activation for lipid binding . In: Biochemistry . 46, No. 28, July 2007, pp. 8445-50. doi : 10.1021 / bi700028u . PMID 17580958 .
  5. ^ Bailey S, Fish PV, Billotte S, et al. : Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents . In: Bioorg. Med. Chem. Lett. . 18, No. 24, December 2008, pp. 6562-7. doi : 10.1016 / j.bmcl.2008.10.036 . PMID 18945617 .
  6. ↑ Reid RR, Mogford JE, R Butt, Degiorgio-Miller A, Mustoe TA: Inhibition of procollagen C-proteinase Reduce scar hypertrophy in a rabbit model of cutaneous scarring . In: Wound Repair Regen . 14, No. 2, 2006, pp. 138-41. doi : 10.1111 / j.1743-6109.2006.00103.x . PMID 16630102 .
  7. ↑ Zhang Y, Ge G, Greenspan DS: Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin . In: J. Biol. Chem. . 281, No. 51, December 2006, pp. 39096-104. doi : 10.1074 / jbc.M601362200 . PMID 17071617 .

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