Konrad Sandhoff

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Konrad Sandhoff (born August 11, 1939 in Berlin ) is a German biochemist .

Career

Konrad Sandhoff was born the son of a chemist in Berlin. In 1958 he graduated from high school in Munich and then studied chemistry at the Ludwig Maximilians University in Munich . He completed his studies with a diploma in 1964 and received his doctorate in Munich in 1965 . In the same year he married. From 1965 to 1979 he worked at the Max Planck Institute for Psychiatry in Munich. He had research stays at the Johns Hopkins University in Baltimore and at the Weizmann Institute in Israel. In 1972 he received his habilitation in biochemistry . From 1979 until his retirement in 2007, Sandhoff was full professor of biochemistry at the Kekulé Institute for Organic Chemistry and Biochemistry at the University of Bonn , and since then has been the senior professor of a research laboratory. From 1992 to 1994 he was Dean and from 1994 to 1996 Vice Dean of the Faculty of Mathematics and Natural Sciences at the Rheinische Friedrich-Wilhelms University in Bonn. From 1991 to 2002 he was the spokesman for the SFB 284 “Glycoconjugates and Contact Structures of the Cell Surface” and from 1992 to 2000 he was elected expert reviewer for biochemistry for the German Research Foundation. Sandhoff has been an Honorary Member of the American Society for Biochemistry and Molecular Biology since 1992. He was President and Vice President of the GBM (1997–2001) and the GDNÄ (2003–2008) and rapporteur for the extended evaluation of research field 4 of the Biological-Medical Section of the Max Planck Society (2000–2001). He has been a member of the NRW Academy since 1994, the national Leopoldina Academy since 1999 and of EMBO since 2000. From 2005 to 2006 he was chairman of the Society of German Natural Scientists and Doctors . He was and is a member of various advisory boards, including a. Member of the Board of Trustees of the Heinrich Wieland Prize (Chairman 2007–2011), the Scientific Advisory Board of the Ara-Parseghian Medical Research Foundation (since 2002), the Selection Committee for Independent Young Investigators of the Max Planck Society (2006–2008), the Board of Trustees of the Bayer Study Foundation (since 2007) and on the Advisory Board of the Max Planck Institute for Molecular Cell Biology and Genetics, Dresden (since 2014). He was also a member of a number of editorial boards for specialist journals, including a. Journal of Neurochemistry, Journal of Biological Chemistry, Angewandte Chemie, Biochimica et Biophysica Acta, Archives of Biochemistry and Biophysics, and Biological Chemistry.

Work areas

Sandhoff works mainly in the area of ​​cellular metabolism . He researches glycosphingolipids , their metabolism, the corresponding cell biology and enzymology at the phase interfaces. The endocytosis and lysosomal degradation of lipids and membranes are additional areas of Sandhoff. The molecular analysis of hereditary diseases led him in 1968 to the first description of the rare lysosomal storage disease, Morbus Sandhoff, later named after him . The molecular causes of other lysosomal storage diseases were clarified in his laboratory.

Awards

Since 2008 he has given 15 name lectures and opening lectures at international congresses.

Publications

Konrad Sandhoff is the author or co-author of over 480 publications in various specialist journals. A small selection:

  • Anheuser, B. Breiden, G. Schwarzmann and K. Sandhoff: Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity. In: Journal of Lipid Research 56, 2015, pp. 1747–1761.
  • G. Schwarzmann, B. Breiden and K. Sandhoff: Membrane-spanning lipids for an uncompromised monitoring of membrane fusion and intermembrane lipid transfer. In: Journal of Lipid Research 56, 2015, pp. 1861-1879.
  • VO Oninla, B. Breiden, JO Babalola and K. Sandhoff: Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2. In: Journal of Lipid Research 55, 2014, pp. 2606-2619.
  • K. Sandhoff and K. Harzer: Gangliosides and gangliosidoses. Principles of molecular and metabolic pathogenesis. In: Journal of Neuroscience 33, 2013, pp. 10195-208.
  • K. Sandhoff: My journey into the world of sphingolipidoses. In: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences 88, 2012, pp. 554-82.
  • T. Kolter and K. Sandhoff: Principles of Lysosomal Membrane Digestion - Stimulation of Sphingolipid Degradation by Sphingolipid Activator Proteins and Anionic Lysosomal Lipids In: Annual Review of Cell and Developmental Biology 21, 2005, pp. 81-103.
  • T. Doering, WM Holleran, A. Potratz, G. Vielhaber, PM Elias, K. Suzuki and K. Sandhoff K: Sphingolipid Activator Proteins Are Required for Epidermal Permeability Barrier Formation. In: Journal of Biological Chemistry 274, 1999, pp 11038-45.
  • T. Kolter and K. Sandhoff: Inhibitors of glycosphingolipid biosynthesis. In: Chemical Society Reviews 25, 1996, pp. 371-381.
  • K. Sandhoff and T. Kolter: Topology of glycosphingolipid degradation. In: Trends in Cell Biology 6, 1995, pp. 98-103.

Individual evidence

  1. ↑ K. Sandhoff et al: Deficient hexosaminidase activity in an exceptional case of Tay-Sachs disease with additional storage of kidney globoside in visceral organs. In: Life Sci 7, 1968, pp. 283-288. PMID 5651108 .
  2. ↑ K. Sandhoff et al.: Enzyme alterations and lipid storage in three variants of Tay-Sachs disease. In: J. Neurochem. 18, 1971, pp. 2469-2489. PMID 5135907
  3. ↑ unknown: Akademie Leopoldina honors the biochemist Prof. Dr. Konrad Sandhoff (Bonn) with the Mendel Medal. dated April 6, 2001
  4. ^ J. Maxton kitchen master: Otto Warburg medal for Konrad Sandhoff. dated April 11, 2006

Web links

personal data
SURNAME Sandhoff, Konrad
BRIEF DESCRIPTION German biochemist
DATE OF BIRTH August 11, 1939
PLACE OF BIRTH Berlin