LFA-3

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Lymphocyte function-associated antigen 3
other names

Surface glycoprotein LFA-3, CD58

Existing structure data : PDB  1CCZ , PDB  1CI5 , PDB  1QA9

Properties of human protein
Mass / length primary structure 250 amino acids , 28,147 Da
Identifier
External IDs
Orthologue (human)
Entrez 27087
Ensemble ENSG00000109956
UniProt P19256
Refseq (mRNA) NM_018644.3
Refseq (protein) NP_061114.2
PubMed search 27087

Lymphocyte function-associated antigen 3 (LFA-3) is a surface protein from the group of glucuronyltransferases .

properties

LFA3 binds to CD2 on T lymphocytes . It is involved in the activation of T-lymphocytes and in the rosetting of erythrocytes on T-lymphocytes. In T cells, this results in antigen- independent cell contact , accelerated cell division of naive T helper cells and induction of interferon-gamma in memory cells . Binding to CD2 also activates the LFA3-carrying cell. LFA-3 is glycosylated and partially has a GPI anchor . Two isoforms with 35 nucleotides difference at the 3 'end are formed from the gene consisting of six exons by alternative splicing , one with a GPI anchor and one with a transmembrane domain .

Some gene variants of LFA-3 are involved in the development of multiple sclerosis .

Web links

Individual evidence

  1. ↑ AG Wingren, E. Parra, M. Varga, T. Kalland, HO Sjögren, G. Hedlund, M. Dohlsten: T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles. In: Critical reviews in immunology. Volume 15, Numbers 3-4, 1995, pp. 235-253, PMID 8834450 .
  2. ^ R. Wallich, C. Brenner, Y. Brand, M. Roux, M. Reister, S. Meuer: Gene structure, promoter characterization, and basis for alternative mRNA splicing of the human CD58 gene. In: Journal of Immunology. Volume 160, Number 6, March 1998, pp. 2862-2871, PMID 9510189 .
  3. ↑ PL De Jager, C. Baecher-Allan, LM Maier, AT Arthur, L. Ottoboni, L. Barcellos, JL McCauley, S. Sawcer, A. Goris, J. Saarela, R. Yelensky, A. Price, V. Leppa, N. Patterson, PI de Bakker, D. Tran, C. Aubin, S. Pobywajlo, E. Rossin, X. Hu, CW Ashley, E. Choy, JD Rioux, MA Pericak-Vance, A. Ivinson, DR Booth, GJ Stewart, A. Palotie, L. Peltonen, B. Dubois, JL Haines, HL Weiner, A. Compston, SL Hauser, MJ Daly, D. Reich, JR Oksenberg, DA Hafler: The role of the CD58 locus in multiple sclerosis. In: Proceedings of the National Academy of Sciences . Volume 106, number 13, March 2009, pp. 5264-5269, doi : 10.1073 / pnas.0813310106 , PMID 19237575 , PMC 2664005 (free full text).