LJ-001

Structural formula
General
Surname	LJ-001
Molecular formula	C 17 H 13 NO 2 S 2
External identifiers / databases
PubChem	2272467
Wikidata	Q18344440
properties
Molar mass	327.42 g mol −1
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

LJ-001 is an experimental antiviral agent against various enveloped RNA viruses .

properties

LJ-001 is effective against the influenza A virus , filoviruses such as the ebola virus , smallpox viruses , arenaviruses , bunyaviruses , paramyxoviruses , flaviviruses and HIV . by inhibiting cell entry ( entry inhibitor ) after adsorption on the cell surface and before fusion with the endosome membrane . In addition, LJ-001 leads to the formation of oxygen radicals , which damage the virus envelope . LJ-001 was discontinued due to instability of the molecule and the need for light to be effective. However, it serves as a lead structure in the development of a new type of antiviral drug.

Individual evidence

↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ MC Wolf, AN Freiberg, T. Zhang, Z. Akyol-Ataman, A. Grock, PW Hong, J. Li, NF Watson, AQ Fang, HC Aguilar, M. Porotto, AN Honko, R. Damoiseaux, JP Miller , SE Woodson, S. Chantasirivisal, V. Fontanes, OA Negrete, P. Krogstad, A. Dasgupta, A. Moscona, LE Hensley, SP Whelan, KF Faull, MR Holbrook, ME Jung, B. Lee: A broad-spectrum antiviral targeting entry of enveloped viruses. In: Proceedings of the National Academy of Sciences of the United States of America . Volume 107, number 7, February 2010, ISSN 1091-6490 , pp. 3157-3162, doi : 10.1073 / pnas.0909587107 , PMID 20133606 , PMC 2840368 (free full text).
^ A. Hollmann, MA Castanho, B. Lee, NC Santos: Singlet oxygen effects on lipid membranes: implications for the mechanism of action of broad-spectrum viral fusion inhibitors. In: Biochemical Journal . Volume 459, number 1, April 2014, ISSN 1470-8728 , pp. 161-170, doi : 10.1042 / BJ20131058 , PMID 24456301 .
^ The Rise and Fall of LJ-001. Memoirs of a Defective Brain, Aug. 19, 2013
↑ F. Vigant, J. Lee, A. Hollmann, LB Tanner, Z. Akyol Ataman, T. Yun, G. Shui, HC Aguilar, D. Zhang, D. Meriwether, G. Roman-Sosa, LR Robinson, TL Juelich, H. Buczkowski, S. Chou, MA Castanho, MC Wolf, JK Smith, A. Banyard, M. Kielian, S. Reddy, MR Wenk, M. Selke, NC Santos, AN Freiberg, ME Jung, B. Lee : A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion. In: PLoS Pathogens . Volume 9, number 4, 2013, p. E1003297, ISSN 1553-7374 , doi : 10.1371 / journal.ppat.1003297 , PMID 23637597 , PMC 3630091 (free full text).
^ E. De Clercq: A Cutting-Edge View on the Current State of Antiviral Drug Development. In: Medicinal Research Reviews . [Electronic publication before printing] March 2013, ISSN 1098-1128 , doi : 10.1002 / med.21281 , PMID 23495004 .

[NV-1] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[2] MC Wolf, AN Freiberg, T. Zhang, Z. Akyol-Ataman, A. Grock, PW Hong, J. Li, NF Watson, AQ Fang, HC Aguilar, M. Porotto, AN Honko, R. Damoiseaux, JP Miller , SE Woodson, S. Chantasirivisal, V. Fontanes, OA Negrete, P. Krogstad, A. Dasgupta, A. Moscona, LE Hensley, SP Whelan, KF Faull, MR Holbrook, ME Jung, B. Lee: A broad-spectrum antiviral targeting entry of enveloped viruses. In: Proceedings of the National Academy of Sciences of the United States of America . Volume 107, number 7, February 2010, ISSN 1091-6490 , pp. 3157-3162, doi : 10.1073 / pnas.0909587107 , PMID 20133606 , PMC 2840368 (free full text).

[3] A. Hollmann, MA Castanho, B. Lee, NC Santos: Singlet oxygen effects on lipid membranes: implications for the mechanism of action of broad-spectrum viral fusion inhibitors. In: Biochemical Journal . Volume 459, number 1, April 2014, ISSN 1470-8728 , pp. 161-170, doi : 10.1042 / BJ20131058 , PMID 24456301 .

[4] The Rise and Fall of LJ-001. Memoirs of a Defective Brain, Aug. 19, 2013

[5] F. Vigant, J. Lee, A. Hollmann, LB Tanner, Z. Akyol Ataman, T. Yun, G. Shui, HC Aguilar, D. Zhang, D. Meriwether, G. Roman-Sosa, LR Robinson, TL Juelich, H. Buczkowski, S. Chou, MA Castanho, MC Wolf, JK Smith, A. Banyard, M. Kielian, S. Reddy, MR Wenk, M. Selke, NC Santos, AN Freiberg, ME Jung, B. Lee : A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion. In: PLoS Pathogens . Volume 9, number 4, 2013, p. E1003297, ISSN 1553-7374 , doi : 10.1371 / journal.ppat.1003297 , PMID 23637597 , PMC 3630091 (free full text).

[6] E. De Clercq: A Cutting-Edge View on the Current State of Antiviral Drug Development. In: Medicinal Research Reviews . [Electronic publication before printing] March 2013, ISSN 1098-1128 , doi : 10.1002 / med.21281 , PMID 23495004 .