MBTPS1
| MBTPS1 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 866 amino acids | |
| Cofactor | Ca 2+ | |
| Identifier | ||
| Gene names | MBPTS1 ; S1P, KIAA0091, SKI-1, PCSK8 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.4.21.112 , serine protease | |
| MEROPS | S08.063 | |
| Substrate | SREBP-SCAP | |
| Products | SREBP-TF | |
| Occurrence | ||
| Homology family | CG6443 PA | |
| Parent taxon | Eukaryotes | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 8720 | 56453 |
| Ensemble | ENSG00000140943 | ENSMUSG00000031835 |
| UniProt | Q14703 | Q9WTZ2 |
| Refseq (mRNA) | NM_003791 | NM_001167910 |
| Refseq (protein) | NP_003782 | NP_001161382 |
| Gene locus | Chr 16: 84.05 - 84.12 Mb | Chr 8: 119.51 - 119.56 Mb |
| PubMed search | 8720 |
56453
|
MBTPS1 (synonyms: S1P, Site-1 protease; others in iHOP ) stands for membrane bound transcription factor protease, site 1 . MBTPS1 is a protease that plays a role in the cholesterol balance of human and many other eukaryotic cells. It belongs to the subtilisin family of serine proteases .
function
This enzyme proteolytically splits the SREBPs (sterol regulatory element binding protein) in human cells and thereby activates them to transcription factors , which then increase the transcription rate of several genes in the cell nucleus (including the genes of HMG-CoA reductase , HMG-CoA synthase , Prenyltransferase and the LDL receptor in their promoter region the SRE ( sterol regulatory element ) to which the activated SREBPs can bind). This only happens if SREBP has previously bound SCAP ( SREBP cleavage activating protein ); this bond is broken when SCAP binds cholesterol. This creates a feedback mechanism that can be described as follows: If there is little cholesterol in the cell, the transcription of several genes, which are necessary for the cell's cholesterol synthesis, is increased, as described above, until the one that is formed Cholesterol binds to SCAP. There are many other feedback mechanisms by which cholesterol inhibits its formation, e.g. HMG-CoA reductase is B. also directly inhibited.
Web links
- MBTPS1. In: Online Mendelian Inheritance in Man . (English).