CCL3

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CCL3
CCL3
according to PDB  1B50
other names
  • Chemokine (CC Motif) ligand 3
  • SCYA3
  • MIP1A
  • Small Inducible Cytokine A3 (Homologous To Mouse Mip-1a)
  • Macrophage Inflammatory Protein 1-Alpha
  • Tonsillar Lymphocyte LD78 Alpha Protein
  • G0 / G1 Switch Regulatory Protein 19-1
  • PAT 464.1
  • SIS beta
  • G0S19-1
  • CC Motif Chemokine 3
  • LD78ALPHA

Existing structural data : 1B50 , 1B53 , 2X69 , 2X6G , 3FPU , 3H44

Properties of human protein
Mass / length primary structure 92 amino acids, 10085 Da
Secondary to quaternary structure Monomer
Identifier
External IDs

CCL3 (synonym MIP1α) is a cytokine from the family of CC chemokines .

properties

CCL3 is involved in inflammatory processes. It binds polymorphonuclear leukocytes by binding the receptors CCR1 , CCR4 and CCR5 . CCL3 is involved in the pathogenesis of chromoblastomycosis and the defense against infections with HIV- 1.

Individual evidence

  1. ↑ Ennan Guan, Jinhai Wang, Michael A. Norcross: Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer . In: The Journal of biological chemistry . 276, No. 15, United States, April 2001, ISSN  0021-9258 , pp. 12404-9. doi : 10.1074 / jbc.M006327200 . PMID 11278300 .