Malonyl-CoA

Structural formula
General
Surname	Malonyl-CoA
other names	Malonyl coenzyme A.
Molecular formula	C 24 H 38 N 7 O 19 P 3 S
External identifiers / databases
CAS number 524-14-1 EC number 208-353-4 ECHA InfoCard 100.007.596 PubChem 46936998 ChemSpider 26330306 DrugBank DB04524 Wikidata Q27095293
properties
Molar mass	853.12 g mol −1
safety instructions
GHS hazard labeling no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Malonyl-coenzyme A (short: malonyl-CoA ) is a thioester of malonic acid with the coenzyme A . Malonyl-CoA is required in the molecular mechanism of fatty acid synthesis . There it plays a central role as Fettsäurekettenverlängerer, as in the biosynthesis of multiple unsaturated fatty acids (. Eg arachidonic acid from linoleic acid ). Here it offers its carbon chain share for fatty acid lengthening (and thus creating space for double bonds). A biotin- dependent enzyme , acetyl-CoA carboxylase (ACC), is required to produce malonyl-CoA . Malonyl-CoA is thus produced by carboxylation from acetyl-CoA ( activated acetic acid ) as a precursor to the formation of fatty acids . The ACC is the pacemaker enzyme for fatty acid biosynthesis . The incorporation of CO ₂ takes place with simple ATP consumption.

In higher organisms, fatty acid biosynthesis takes place predominantly in the liver .

literature

• Peter C. Heinrich, Georg Löffler, Petro E. Petrides, Matthias Müller, Lutz Graeve (Eds.): Löffler-Petrides Biochemistry and Pathobiochemistry . 9th, completely revised Edition. Springer Medicine, Berlin, Heidelberg 2014, ISBN 978-3-642-17971-6 .

Individual evidence

1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.