Mansukh C. Wani

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Monroe Wall (left) and Mansukh Wani

Mansukh C. Wani (born February 20, 1925 in Nandurbar , Nandurbar (District) , Maharashtra ; † April 11, 2020 in Durham , North Carolina ) was an Indian-American chemist who worked with Monroe E. Wall to develop chemotherapeutic agents against cancer Discovered paclitaxel and camptothecin .

Wani went to high school in Nandurbar with the degree in 1943 and studied chemistry at the University of Bombay with a bachelor's degree in 1947 and a master's degree in organic chemistry in 1950. In 1958 he went to the United States and was in 1962 at Indiana University PhD in chemistry. He was a post-doctoral student at the University of Wisconsin-Madison . From 1962 he was at the Research Triangle Institute (later RTI International) in the Research Triangle , where he became a Principal Scientist.

In the 1960s he and Wall systematically investigated numerous plant and animal extracts for their effectiveness as chemotherapeutic agents against cancer (and for contraception). In 1966 they published their results on camptothecin, which they obtained from a Chinese tree, and in 1971 on paclitaxel (taxol) from the yew tree. Both became major cancer chemotherapy drugs, which together accounted for a third of the cancer chemotherapy drug market in 2002. He also worked on the synthesis of water-soluble camptothecin analogs.

He has over 200 publications and held 36 patents.

In 2000 he received the Kettering Prize with Monroe E. Wall . He also received the Bruce F. Cain Memorial Award from the American Association for Cancer Research, the City of Medicine Award from the Greater Durham Chamber of Commerce, and the National Cancer Institute Award of Recognition. In 2005 he received the North Carolina Award in Science and in 2008 the Paul Ehrlich Magic Bullet Lifetime Achievement Award, and he received the Ranbaxy Research Award and the Distinguished Alumni Award from Indiana University. In 2003 the American Chemical Society named RTI a National Historic Chemical Landmark for the discovery of taxol and camptothecin.

Web links

Individual evidence

  1. ↑ Mansukh Wani, codiscoverer of Taxol, dies at age 95. Retrieved June 6, 2020 .
personal data
SURNAME Wani, Mansukh C.
BRIEF DESCRIPTION Indian-American chemist
DATE OF BIRTH February 20, 1925
PLACE OF BIRTH Nandurbar
DATE OF DEATH April 11, 2020
Place of death Durham , North Carolina