Methoxylation
As methoxylation is known in the chemistry a reaction to the introduction of one or more methoxy groups .
The methoxy group consists of a methyl group and an oxygen atom and is a functional group in an organic chemical compound. Methoxy groups are found as a functional group of methyl ethers, methyl esters , hemiacetals derived from methanol and full acetals .
Examples of manufacture
- Preparation of methyl tert -butyl ether ( MTBE ) by catalytic addition of methanol to isobutene .
- Production of ethyl methyl ether by nucleophilic substitution from sodium methoxide and ethyl bromide .
- Production of methyl benzoate from benzoic acid and methanol with acid catalysis.
- Formation of hemiacetals through the acid-catalyzed reaction of aldehydes (or ketones ) with methanol. The hemiacetals react under acid catalysis with methanol with elimination of water to form full acetals.
- The reaction of N -acylimminium salts with methanol in the presence of suitable bases gives an N -acyl- N , O- acetals containing methoxy groups .
Use (selection)
- 4-Methoxybenzoic acid was previously used as a local anesthetic and anti-inflammatory drug.
- 4-methoxyacetophenone is an important fragrance with a smell similar to hawthorn or anisaldehyde.
Individual evidence
- ↑ K. Schulz, M. Watzke, K. Johannes, P. Ullrich, J. Martens : Synthesis of Bi- and Tricyclic α, β-Unsaturated Lactams as Potential Michael Acceptors Starting from Heterocyclic Imines. In: Synthesis , 2009 , pp. 665-673.
- ↑ a b Otto-Albrecht Neumüller (Ed.): Römpps Chemie-Lexikon. Volume 4: M-Pk. 8th revised and expanded edition. Franckh'sche Verlagshandlung, Stuttgart 1985, ISBN 3-440-04514-5 , p. 2577.