Mevalonate kinase
| Mevalonate kinase | ||
|---|---|---|
|
||
| Properties of human protein | ||
| Mass / length primary structure | 396 amino acids | |
| Secondary to quaternary structure | Homodimer | |
| Identifier | ||
| Gene name | MVK | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.7.1.36 , kinase | |
| Response type | Phosphorylation | |
| Substrate | ATP + mevalonate | |
| Products | ADP + 5-phosphomevalonate | |
| Occurrence | ||
| Parent taxon | Eukaryotes | |
The mevalonate kinase (MK) is the enzyme that in eukaryotes the phosphorylation of mevalonate catalyzes a partial step in the biosynthesis of isoprenoids . MK is localized in the cytosol of the peroxisomes . When people can mutations in the MVK - gene for hereditary mevalonate kinase deficiency and Hyperimmunoglobulinemia result of type D.
Catalyzed reaction
-Mevalonat.svg){kind=small}
+ ATP ⇔ -5-Phosphomevalonat.svg){kind=small}
+ ADP
R- evalonate is converted to 5-phospho- R -mevalonate.
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Cholesterol Biosynthesis - Learning and Teaching Materials
- Jassal / reactome: Mevalonate is phosphorylated to mevalonate-5-phosphate
- OrphaNet: Mevalonic aciduria
- OrphaNet: Hyperimmunoglobinemia D with recurrent fever