Michael Neumaier

from Wikipedia, the free encyclopedia

Michael Neumaier (born January 20, 1958 in Bonn ) is a German specialist in laboratory medicine and clinical chemist, who has held the chair for clinical chemistry at the Mannheim Medical Faculty of the University of Heidelberg since 2002 and, as a university professor, the Institute for Clinical Chemistry of the University Medicine Mannheim ( UMM).

Life

Michael Neumaier studied human medicine from 1979 to 1985 at the Rheinische Friedrich-Wilhelms-Universität Bonn , where he received his doctorate in 1986 (title of the doctoral thesis: " Isolation of carcinoembryonic antigens and CEA-like antigens using monoclonal immunoabsorbents: immunochemical characterization using transblots and structural analysis " ). From 1986 to 1988 he was a "Research Fellow" of the German Research Foundation (DFG) and worked on the molecular cloning of members of the CEA family (Carcinoembrional Antigen) and the genetic production of monoclonal antibodies at the City of Hope National Medical Center in Duarte, California. After his return from the USA, he worked from 1988 as a scientific assistant at the Institute for Clinical Chemistry and Pathobiochemistry at the University Clinic of the Rheinisch-Westfälische Technische Hochschule Aachen and in 1991 moved to the University Clinic Hamburg-Eppendorf . He was recognized as a clinical chemist in 1992. In 1994 Michael Neumaier completed his habilitation in clinical chemistry and immunology (title of the habilitation thesis: “ Cloning and molecular characterization of a monoclonal idiotype cascade with specificity for the human carcinoembryonic antigen: a concept for specific immunodiagnostics as well as passive and active immunotherapy for colorectal cancer ”) at the Medical Faculty of the University of Hamburg, where he received a C3 professorship in 1996 . In 2002 he accepted the professorship for Clinical Chemistry at the University Medical Center Mannheim at the University of Heidelberg, where he heads the Institute for Clinical Chemistry.

Offices and memberships

Michael Neumaier has been a member of the Presidium of the Mannheim Medical Faculty at Heidelberg University since 2013, was Dean of Studies from 2013 to 2015 and has been Vice Dean since 2015 .

From 2012 to 2015 Michael Neumaier was a member of the Presidium of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL) and held the office of President from 2014 to 2015. In 2009 he founded the "Molecular Diagnostics" section of the DGKL , which he headed until 2013. He is also a founding member, former chairman and current member of the DGKL working groups “Molecular and Chip Diagnostics”, “ Bioinformatics ” and “ Biobanks ”.

Michael Neumaier is the named ring test leader for clinical chemistry and molecular diagnostics at the Reference Institute for Bionanalytics (RfB). He has been a member of the scientific advisory board of the RfB since 1998 and was chairman of the advisory board from 2011 to 2015. Since 2004 he has been head of the Reference Institute for Molecular Genetic Diagnostics at the RfB. He is the acting director of the national "External Quality Assessment in Laboratory Medicine" program, for which he was appointed by the German Medical Association (BÄK). He is a member of the advisory board of the BÄK and chairman of the specialist group D5 “Molecular genetic and cytogenetic laboratory tests”. Michael Neumaier is a founding member of the German National Gene Diagnostics Commission (GenDG) of the German federal government at the Robert Koch Institute in Berlin.

Michael Neumaier is a founding member of the Committee for Clinical Molecular Biology Curriculum (C-CMBC / EMD) of the Education and Management Division of the International Federation of Clinical Chemistry (IFCC), which has been in existence since 2004 . He was also a member of the EC4 Commission of the “European Communities Confederation of Clinical Chemistry”. He has been a member of the Cancer Genomics (C-CG) Working Groups of the IFCC and a member of the IFCC Task Force for Pharmacogenetics since 2015 .

From March 2016 to January 2018 Michael Neumaier was Vice President of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM), of which he has been acting President since 2018.

plant

Michael Neumaier's scientific focus is on oncology , immunology and quality assurance of complex, diagnostic procedures in laboratory medicine. The importance of quality assurance in laboratory diagnostics and molecular genetic diagnostics in particular, he was able to demonstrate and develop further in numerous publications. Furthermore, he has dealt with more recent scientific work on preanalytical aspects of the biomolecular quality of clinical samples and research samples in biobanks .

One focus of his work was the elucidation of the mechanisms of early colorectal tumorigenesis and the function of the carcinoembryonic antigen (CEA). In addition, his working group was one of the first to describe the so-called third immune system (in addition to the humoral and T-cell-mediated systems) and was able to show that myeloid cells express variable immune receptors. The diagnosis of molecular tumor markers in the form of cell-free somatic mutated tumor DNA, also known as liquid profiling or liquid biopsy , for the early detection of a relapse and possible resistance to therapy in the plasma of cancer patients represents a further field of research and has now been incorporated into routine clinical diagnostics.

Main publications

Michael Neumaier has published more than 100 scientific papers, including:

  • M. Neumaier, L. Shively, F. Chen, F. Gaida, C. Ilgen, R. Paxton, J. Shively, A. Riggs: Cloning of the genes for T84.66, an antibody that has a high specificity and affinity for carcinoembryonic antigen, and expression of chimeric human / mouse T84.66 genes in myeloma and Chinese hamster ovary cells . In: Cancer Res. 1990; 50 (7): 2128-34 .
  • M. Neumaier, S. Paululat, A. Chan, P. Matthaes, C. Wagener: Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. In: Proceedings of the National Academy of Sciences . 1993; 90 (22): 10744-8. PMC 47854 (free full text).
  • M. Gerhard, H. Juhl, H. Kalthoff, H. Schreiber, C. Wagener, M. Neumaier: Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction. In: Journal of Clinical Oncology. 1994; 12 (4): 725-9. doi: 10.1200 / JCO.1994.12.4.725 .
  • A. Braun, T. Deufel, W. Geilenkeuser, M. Neumaier, G. Röhle, A. Roscher, C. Wagener: External quality assessment of molecular biology-based methods used in laboratories of clinical chemistry and human genetics. In: Clinical chemistry and laboratory medicine. 1998; 36 (4): 231-4. doi: 10.1515 / CCLM.1998.039
  • M. Neumaier, A. Braun, C. Wagener: Fundamentals of quality assessment of molecular amplification methods in clinical diagnostics. In: Clinical Chemistry. 1998; 44 (1): 12-26. ISSN  0009-9147 ( PDF )
  • S. Nittka, J. Gunther, C. Ebisch, A. Erbersdobler, M. Neumaier: The human tumor suppressor CEACAM1 modulates apoptosis and is implicated in early colorectal tumorigenesis. In: Oncogene. 2004; 23 (58): 9306-13. doi: 10.1038 / sj.onc.1208259
  • P. Findeisen, D. Sismanidis, M. Riedl, V. Costina, M. Neumaier: Preanalytical impact of sample handling on proteome profiling experiments with matrix-assisted laser desorption / ionization time-of-flight mass spectrometry. In: Clinical chemistry. 2005; 51 (12): 2409-11. doi: 10.1373 / clinchem.2005.054585
  • P. Ahmad-Nejad, A. Dorn-beinke, U. Pfeiffer, J. Brade, W. Geilenkeuser, S. Ramsden, M. Pazzagli, M. Neumaier. Methodologic European external quality assurance for DNA sequencing: the EQUALseq program . In: Clinical chemistry. 2006; 52 (4): 716-27. doi: 10.1373 / clinchem.2005.061572
  • P. Findeisen, S. Post, F. Wenz, M. Neumaier: Addition of exogenous reporter peptides to serum samples before mass spectrometry-based protease profiling provides advantages over profiling of endogenous peptides. In: Clinical chemistry. 2007; 53 (10): 1864-6. doi: 10.1373 / clinchem.2006.083030
  • V. Haselmann, P. Ahmad-Nejad, W. Geilenkeuser, A. Duda, M. Gabor, R. Eichner, S. Patton, M. Neumaier: Results of the first external quality assessment scheme (EQA) for isolation and analysis of circulating tumor DNA (ctDNA). In: Clinical Chemistry and Laboratory Medicine (CCLM). 2017. doi: 10.1515 / cclm-2017-0283

Honors

In 1993 Michael Neumaier was honored by the Werner Otto Foundation for advances in medicine, in 1994 he received the Gábor Szász Prize of the German Society for Clinical Chemistry (DGKC) and in 1998 the Konietzny Award of the Cancer Society in Hamburg. Michael Neumaier has been visiting professor at the University of Zagreb since 2007. In 2011 he was awarded the Abbott Award of the International Society of Clinical Chemistry and Laboratory Medicine (IFCC) at the IFCC World Congress in Berlin for the establishment of a Europe-wide network for quality assurance in molecular genetic studies.

Individual evidence

  1. ↑ University Medicine Mannheim: :: Institute for Clinical Chemistry - UMM University Medicine Mannheim: Institute for Clinical Chemistry ::. Retrieved May 17, 2018 .
  2. ↑ https://beluga.sub.uni-hamburg.de/vufind/Record/01009492X?rank=2. Retrieved January 17, 2018 .
  3. ↑ https://beluga.sub.uni-hamburg.de/vufind/Record/043579256?rank=1. Retrieved January 17, 2018 .
  4. ↑ Verena Haselmann, Wolf J. Geilenkeuser, Simona Helfert, Romy Eichner, Svetlana Hetjens: Thirteen Years of an International External Quality Assessment Scheme for Genotyping: Results and Recommendations . In: Clinical Chemistry . tape 62 , no. 8 , August 1, 2016, ISSN  0009-9147 , p. 1084-1095 , doi : 10.1373 / clinchem.2016.254482 , PMID 27324736 ( aaccjnls.org [accessed January 17, 2018]).
  5. ↑ Andreas Braun, Thomas Deufel, Wolf-Jochen Geilenkeuser, Michael Neumaier, Gerhard Röhle: External Quality Assessment of Molecular Biology-Based Methods Used in Laboratories of Clinical Chemistry and Human Genetics . In: Clinical Chemistry and Laboratory Medicine . tape 36 , no. 4 , April 30, 1998, ISSN  1434-6621 , doi : 10.1515 / cclm.1998.039 .
  6. Jump up ↑ Peter Findeisen, Diamandula Sismanidis, Martin Riedl, Victor Costina, Michael Neumaier: Preanalytical Impact of Sample Handling on Proteome Profiling Experiments with Matrix-Assisted Laser Desorption / Ionization Time-of-Flight Mass Spectrometry . In: Clinical Chemistry . tape 51 , no. 12 , December 1, 2005, ISSN  0009-9147 , p. 2409-2411 , doi : 10.1373 / clinchem.2005.054585 , PMID 16306114 ( aaccjnls.org [accessed January 17, 2018]).
  7. ↑ Parviz Ahmad-Nejad, Alexandra Dorn-beinke, Ulrike Pfeiffer, Joachim Brade, Wolf-Jochen Geilenkeuser: Methodologic European External Quality Assurance for DNA Sequencing: The EQUALseq Program . In: Clinical Chemistry . tape 52 , no. 4 , April 1, 2006, ISSN  0009-9147 , p. 716-727 , doi : 10.1373 / clinchem.2005.061572 , PMID 16439604 ( aaccjnls.org [accessed January 17, 2018]).
  8. ↑ Alexander W. Beham, Kerstin Puellmann, Rebecca Laird, Tina Fuchs, Roswita Streich: A TNF-Regulated Recombinatorial Macrophage Immune Receptor Implicated in Granuloma Formation in Tuberculosis . In: PLOS Pathogens . tape 7 , no. 11 , November 17, 2011, ISSN  1553-7374 , p. e1002375 , doi : 10.1371 / journal.ppat.1002375 ( plos.org [accessed January 17, 2018]).
  9. ↑ http://www.werner-otto-stiftung.de/de/preis/preistraeger.php
  10. ↑ https://www.degruyter.com/view/j/labm.1995.19.issue-1-12/labm.1995.19.1-12.49/labm.1995.19.1-12.49.xml
  11. ↑ http://kongreszagreb2018.hdmblm.hr/index.php/en/program-en/plenary-lecturers
  12. ↑ http://kongreszagreb2018.hdmblm.hr/index.php/en/program-en/plenary-lecturers
personal data
SURNAME Neumaier, Michael
BRIEF DESCRIPTION German specialist in laboratory medicine and clinical chemist
DATE OF BIRTH 20th January 1958
PLACE OF BIRTH Bonn