Tumor markers are proteins , peptides or other biological substances in the blood that are found in tissue or other body fluids . Their increased concentration can indicate a tumor or a recurrence of a tumor. Owing to their often low specificity , most tumor markers are less suitable for screening than for monitoring the progression of cancer. Tumor markers are among the biomarkers .
Examples of individual representatives
Some tumor markers are better known by their abbreviations than by their full names.
abbreviation
Surname
Tumor disease
AFP
Alpha-1 fetoprotein
Hepatocellular carcinoma and gonadal and extragonadal germ cell tumors
-
Bence Jones protein (immunoglobulin light chain)
Multiple myeloma
β-hCG
Human chorionic gonadotropin , β subunit
Germ cell tumors of the ovary and non-seminomatous tumors of the testicle
β2MG
β 2 -microglobulin
Malignant lymphomas
CA 15-3 (= MUC-1)
Mucin-1 (Cancer Antigen 15-3)
Breast cancer (breast cancer) or ovarian cancer ( ovarian cancer )
CA 19-9
Cancer antigen 19-9
gastrointestinal malignancies, especially in pancreatic cancer (pancreatic cancer)
APPROX. 50
Cancer antigen 50
Gastrointestinal tract tumors
CA 72-4
Cancer antigen 72-4
Gastric cancer as well as mucinous ovarian cancer
CA 125
Cancer antigen 125
Ovarian cancer ( ovarian cancer )
HE4
Human epididymal protein 4
Ovarian cancer ( ovarian cancer )
-
Calcitonin
medullary thyroid carcinoma
CEA
Carcino embryonic antigen
Colon cancer , pancreatic cancer and adenocarcinoma of the lungs
-
Chromogranin
neuroendocrine tumors
CYFRA 21-1
Cytokeratin 19 fragment
Squamous cell carcinoma of the lungs ( bronchial carcinoma )
HVS
Homovanillic acid
Neuroblastoma
5-HIES
5-hydroxyindolylacetic acid
Carcinoid
VMS
Vanillin-mandelic acid
Pheochromocytoma
LDH
Lactate dehydrogenase
a general marker for rapidly growing tumors
-
Metanephrine
Pheochromocytoma
NSE
Neuron-specific enolase
small cell lung carcinoma (SCLC), neuroblastoma and seminomatous germ cell tumors
PLAP
Placental alkaline phosphatase
seminomatous germ cell tumors
PPE
Prostate-specific antigen
Prostate cancer (prostate cancer)
PSMA
Prostate-specific membrane antigen
Prostate cancer
PKM2 (= M2-PK)
Pyruvate kinase M2
Breast cancer , renal cell carcinoma , bronchial carcinoma , colorectal carcinoma , pancreatic carcinoma , ovarian carcinoma , prostate carcinoma, gastric carcinoma , esophageal carcinoma , cervical carcinoma
S100
S-100 proteins , β subunit
Malignant melanoma
SCC
Squamous Cell Carcinoma Antigen
Bronchial carcinoma
TG
Thyroglobulin
papillary or follicular thyroid cancer
TK
Thymidine kinase
Leukemia , Non-Hodgkin Lymphoma , Multiple Myeloma
TPA
Tissue Polypeptide Antigen
Ovarian carcinoma , prostate carcinoma , bladder carcinoma
-
Tryptase
Systemic mastocytosis
Endocrine-active tumors
In endocrine-disrupting tumors, i.e. tumors that produce hormones such as insulinoma , carcinoid , VIPoma , glucagonoma , gastrinoma , prolactinoma , pheochromocytoma, etc., the corresponding hormones or their breakdown products can be used as tumor markers, provided they do not have a too short half-life.
source
↑ http://www.krebsinformationsdienst.de/untersprüfung/tumormarker.php krebsinformationsdienst.de of the German Cancer Research Center
↑ a b c d e (AFP) in Page 746 in: Manual of Clinical Oncology, Lippincott Manual Series; Dennis Albert Casciato, Mary C. Territo editor Dennis Albert Casciato, Mary C. Territo; Contributor Mary C. Territo; Edition 6, illustrated; Lippincott Williams & Wilkins; 2008; ISBN 978-0-7817-6884-9
See also
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