Homovanillic acid
| Structural formula | |||||||||||||||||||
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| General | |||||||||||||||||||
| Surname | Homovanillic acid | ||||||||||||||||||
| other names |
4-hydroxy-3-methoxyphenylacetic acid |
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| Molecular formula | C 9 H 10 O 4 | ||||||||||||||||||
| Brief description |
yellow-brown powder |
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| properties | |||||||||||||||||||
| Molar mass | 182.17 g mol −1 | ||||||||||||||||||
| Physical state |
firmly |
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| Melting point |
142-145 ° C |
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| safety instructions | |||||||||||||||||||
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | |||||||||||||||||||
Homovanillic acid (HVS, engl .: HVA = homovanillic acid) is the degradation product of dopamine . This is converted into 3-methoxytyramine and finally into homovanillic acid via several intermediate stages . Three enzymes are involved in the conversion : monoamine oxidase (MAO), catechol-O-methyltransferase (COMT) and aldehyde dehydrogenase .
Homovanillic acid can serve as a tumor marker in neuroblastoma as well as in malignant pheochromocytoma . The quantitative determination in urine samples can be carried out together with other metabolites of biogenic amines by gas chromatography after extraction and pre-separation by lipophilic gel chromatography .
Individual evidence
- ↑ a b c d Data sheet Homovanillic acid, 98 +% from AlfaAesar, accessed on December 7, 2019 ( PDF )(JavaScript required) .
- ↑ HU Melchert, H. Hoffmeister: Determination of the urinary metabolites hydroxyindole-acetic acid, vanillyl mandelic acid and homovanillic acid by means of lipophilic gel chromatography and gas chromatography. In: J Clin Chem Clin Biochem. Volume 15, No. 2, Feb 1977, pp. 81-87. PMID 845547 .