Prostate-specific membrane antigen

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Prostate-specific membrane antigen
Prostate-specific membrane antigen

Existing structural data: see UniProt entry

Mass / length primary structure 750 amino acids
Secondary to quaternary structure non-covalent heterodimer
Identifier
External IDs
Enzyme classification
EC, category 3.4.17.21 ,  carboxypeptidase
Response type hydrolysis
Substrate Peptides

Prostate-specific membrane antigen ( PSMA ) (synonyms: glutamate carboxypeptidase II , NAALADase I = N-acetyl-L-aspartyl-L-glutamate peptidase I , folate hydrolase I ) is a membrane-bound glycoprotein . PSMA has the function of an enzyme . It is a carboxypeptidase that the C-terminus of glutamic acid cleaves. In humans, the gene coding for PSMA is found on chromosome 11 gene locus p11.12.

description

PSMA is found on normal prostate cells and prostate cancer cells . It is also found on cells of the neovasculature (newly formed vessels) of other solid tumor types . With the progression and metastasis degree that takes expression to PSMA. Its high specificity makes it an ideal target antigen as a tumor marker for new therapeutic approaches against prostate carcinoma. PSMA-specific monoclonal antibodies can be used in positron emission tomography for diagnostic purposes .

The human PSMA consists of 750 amino acids . The unmodified polypeptide has a molar mass of 84  kDa . Depending on the tissue type and species , 10 to 30% of this is subject to post-translational modification . The molar mass is then typically around 100 kDa.

See also

Individual evidence

  1. ↑ N. Schülke, OA Varlamova u. a .: The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy. In: Proceedings of the National Academy of Sciences . Volume 100, Number 22, October 2003, pp. 12590-12595, ISSN  0027-8424 . doi : 10.1073 / pnas.1735443100 . PMID 14583590 . PMC 240662 (free full text).
  2. ↑ FOLH1 From : genenames.org Retrieved June 24, 2013.
  3. ↑ Davis MI, Bennett MJ, Thomas LM, Bjorkman PJ: Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase. In: Proceedings of the National Academy of Sciences . Volume 102, Number 17, April 2005, pp. 5981-5986, ISSN  0027-8424 . doi : 10.1073 / pnas.0502101102 . PMID 15837926 . PMC 556220 (free full text).
  4. ↑ P. Bühler, P. Wolf, U. Elsässer-Beile: Targeting the prostate-specific membrane antigen for prostate cancer therapy. In: Immunotherapy. Volume 1, Number 3, May 2009, pp. 471-481, ISSN  1750-7448 . doi : 10.2217 / imt.09.17 . PMID 20635963 . (Review).
  5. ↑ MR Feneley, H. Jan u. a .: Imaging with prostate-specific membrane antigen (PSMA) in prostate cancer. In: Prostate Cancer and Prostatic Diseases . 2000; 3: pp. 47-52. doi : 10.1038 / sj.pcan.4500390 . PMID 12497162 .
  6. ↑ C. Barinka, P. Sácha u. a .: Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity. In: Protein science. Volume 13, Number 6, June 2004, pp. 1627-1635, ISSN  0961-8368 . doi : 10.1110 / ps.04622104 . PMID 15152093 . PMC 2279971 (free full text).
  7. ↑ Prostate-specific membrane antigen.  In: Online Mendelian Inheritance in Man . (English)