Michael R. Hayden

from Wikipedia, the free encyclopedia

Michael Reuben Hayden (* 1951 in Cape Town ) is a Canadian doctor and geneticist who is known for researching the hereditary disease Huntington's disease and its genetics as well as for other hereditary diseases, especially of genetic defects in disorders of lipid metabolism.

Michael Hayden

Life

Hayden graduated from the University of Cape Town in 1975 with a degree in medicine and received a PhD in genetics in 1979. He then went to Harvard Medical School for specialist training (internal medicine, medical genetics) and was a doctor at Boston Children's Hospital . In 1983 he went to the University of British Columbia as a professor , where he is the Killam Professor of Medical Genetics and holds a Canada Research Chair in Human Genetics and Molecular Medicine. He is the founder and director of the Center for Molecular Medicine and Therapeutics in Vancouver and is affiliated with the Child & Family Research Institute of the British Columbia Children's Hospital.

plant

In 1998, at the same time as Gerd Schmitz's group, he localized the gene for ABCA 1 , which causes Tangier's disease in mutated form and which codes for a transport protein for cholesterol from the cell, the disruption of which can lead to a lower HDL concentration in the blood serum, the protein that transports cholesterol in blood serum to the liver. He also found that for the hereditary disease hyperchylomicronemia ( lipoprotein lipase deficiency) and developed a gene therapy for it.

In the early 1990s, he identified genetic defects that are responsible for Huntington's disease (the disease was already the subject of his dissertation and a book resulting from it, which appeared in 1981). In 2001 he found that Huntington's disease has mutated a protein (huntingtin) in the nervous system, which is necessary for the transcription of a nerve growth factor (BDNF), which in turn is important for maintaining the nerves in the striatum that die when BDNF is deficient. In 2006 he discovered in studies on the mouse model that the blockade of the enzyme caspase 6 prevents the juvenile the progression of the development of Huntington's disease, which is a possible therapeutic approach. With the discovery of the cause in mutant huntingtin, several drugs are in the development phase (2015), and Hayden and colleagues developed a test in 2015 that shows the levels of the harmful mutant protein in patients.

He also explores the genetic basis of the development of severe side effects on drugs in children.

He is Scientific Director of the Translation Laboratory for Medical Genetics in Singapore and Senior Scientist (Chief Scientific Officer responsible for global research and development) of Teva Pharmaceutical Industries , a leading generic manufacturer based in Israel. He founded three startups himself: Xenon Genetics (with the first approved gene therapeutic Glybera), NeuroVir and Aspreva Pharmaceuticals (sold in 2007 for around $ 900 million). He has been the head of the Canada Genetic Disease Network since its inception in 1990.

Memberships and honors

He is a Fellow of the Royal Society of Canada (1995) and the Canadian Academy of Health Sciences, is a member of the Order of Canada (2010) and the Order of British Columbia (2009). In 2008 he was named Health Researcher of the Year for the Canadian Institutes of Health Research and in 2011 he received the Gairdner Foundation Wightman Award . In 2009 he received an honorary doctorate from the University of Alberta. In 2012 he received The Diamond Jubilee Medal from Queen Elisabeth II. In 2014 he was awarded an honorary doctorate from the University of Göttingen . In 2017, Hayden was inducted into the Canadian Medical Hall of Fame .

Private

His Jewish grandfather Max Raphael Hahn was a successful businessman in Göttingen and had a large Judaica collection that was confiscated by the Nazis during the Night of the Pogroms in 1938 and has been lost. The grandparents were deported to Riga in 1941 and murdered there. His father Rudolf Hahn emigrated to Cape Town and changed the name to "Roger Hayden".

Hayden endeavored to localize and restore his grandfather's outstanding Judaica collection and commissioned a catalog about it in 2011. In 2019 the Vancouver Holocaust Education Center is hosting an exhibition on the history of the family and its collection.

Michael R. Hayden is married with four children.

Fonts

  • Huntington's chorea . Springer, 1981
  • with others: Loss of huntingtin-mediated BDNF gene transcription in Huntington's Disease . In: Science , Vol. 293, 2001, pp. 493-498, PMID 11408619
  • with others: The relationship between trinucleotide repeat length (CAG) and clinical features of Huntington disease . In: Nature Genetics , Volume 4, pp. 398-403, PMID 8401589
  • with others: A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration . In: Neuron , Vol. 23, 1999, pp. 181-192, PMID 10402204

Web links

Individual evidence

  1. ^ Claudia Cornwall: Michael Hayden, In The Genes, BCBusiness April 1, 2008
  2. ↑ Brooks-Wilson, Hayden et al. a .: Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency . In: Nature Genetics , Vol. 22, 1999, pp. 336-345, PMID 10431236
  3. ↑ Graham, Hayden et al. a .: Cleavage at the caspase 6 site in huntingtin is required for motor dysfunction, neurodegeneration and excitotoxicity in Huntington Disease . In: Cell , Vol. 125, 2006, pp. 1179-1191, PMID 16777606
  4. ↑ New test measures effectiveness of treatments for Huntington's disease . In: Science Daily , August 8, 2015
  5. ↑ For example, hearing loss during chemotherapy with cisplatin : Ross, Hayden u. a .: TPMT and COMT genetic variants are predictive for severe hearing loss in children receiving cisplatin chemotherapy . In: Nature Genetics , Volume 41, 2009 pp. 1345-1349, PMID 19898482
  6. ^ Göttinger Tagblatt, honorary doctorate for Hayden
  7. ^ Anna Silman: How One of the World's Leading Geneticists Recovered His Family's Stolen Legacy , Tablet, June 22, 2015
  8. ^ The Hahn and Hayden Collections: A Legacy of Loss, Courage and Revival.
  9. ↑ Family treasures looted during Germany's Kristallnacht on display for the first time at Vancouver exhibition , accessed on November 11, 2019
personal data
SURNAME Hayden, Michael R.
ALTERNATIVE NAMES Hayden, Michael Reuben (full name)
BRIEF DESCRIPTION Canadian medic
DATE OF BIRTH 1951
PLACE OF BIRTH Cape Town