N-acylglucosamine-2-epimerase

from Wikipedia, the free encyclopedia
Renin binding protein
Properties of human protein
Mass / length primary structure 48.8 kilodaltons / 427 amino acids (isoform 1)

29.3 kilodaltons / 254 amino acids (isoform 2)

Cofactor ATP
Isoforms 2
Identifier
Gene names RENBP RBP; RNBP
External IDs
Enzyme classification
EC, category 5.1.3.8
Substrate N- acyl- D -glucosamine
Products N- acyl- D- mannosamine
Orthologue
human House mouse
Entrez 5973 19703
Ensemble ENSG00000102032 ENSMUSG00000031387
UniProt P51606 P82343
Refseq (mRNA) NM_002910 NM_001164704
Refseq (protein) NP_002901 NP_001158176
Gene locus Chr X: 153.94 - 153.94 Mb Chr X: 73.92 - 73.93 Mb
PubMed search 5973 19703

N -Acylglucosamin-2- epimerase is an enzyme that in humans by the RENBP - gene encodes is.

The gene product inhibits renin activity by forming a dimer with renin - a complex known as high molecular weight renin . The encoded protein contains a leucine - zipper - domain , which is essential for the dimerization with renin. The gene product can catalyze the conversion of N -acetylglucosamine to N -acetylmannosamine , which is characteristic of a GlcNAc-2 epimerase . Transcript variants that use alternative promoters have already been described in more detail in the literature.

Individual evidence

  1. ↑ Takahashi S, Inoue H, Miyake Y: The human gene for renin-binding protein . In: J Biol Chem . 267, No. 18, Aug 1992, pp. 13007-13. PMID 1618798 .
  2. ↑ a b Entrez Gene: RENBP renin binding protein . Retrieved September 22, 2014.

literature

  • Inoue H, Takahashi S, Fukui K, Miyake Y: Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif . In: J Biochem . 110, No. 4, 1992, pp. 493-500. PMID 1723410 .
  • Takahashi S, Miura R, Miyake Y: A study on renin binding protein (RnBP) in the human kidney . In: J. Biochem. . 97, No. 2, 1985, pp. 671-7. PMID 3924907 .
  • Murakami K, Hirose S, Chino S, et al. : Properties of renin-binding protein . In: Clinical and Experimental Hypertension . Part A, Theory and Practice . 4, No. 11-12, 1983, pp. 2073-81. doi : 10.3109 / 10641968209062372 . PMID 6756682 .
  • Faranda S, Frattini A, Vezzoni P: The human genes encoding renin-binding protein and host cell factor are closely linked in Xq28 and transcribed in the same direction . In: Genes . 155, No. 2, 1995, pp. 237-9. doi : 10.1016 / 0378-1119 (94) 00810-F . PMID 7721097 .
  • van den Ouweland AM, Verdijk M, Kiochis P, et al. : The human renin-binding protein gene (RENBP) maps in Xq28 . In: Genomics . 21, No. 1, 1994, pp. 279-81. doi : 10.1006 / geno.1994.1259 . PMID 8088804 .
  • Knöll A, Schunkert H, Reichwald K, et al. : Human renin binding protein: complete genomic sequence and association of an intronic T / C polymorphism with the prorenin level in males . In: Hum. Mol. Genet. . 6, No. 9, 1998, pp. 1527-34. doi : 10.1093 / hmg / 6.9.1527 . PMID 9285790 .
  • Brenner V, Nyakatura G, Rosenthal A, Platzer M: Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse . In: Genomics . 44, No. 1, 1997, pp. 8-14. doi : 10.1006 / geno.1997.4822 . PMID 9286695 .
  • Stasche R, Hinderlich S, Weise C, et al. : A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase / N-acetylmannosamine kinase . In: J. Biol. Chem. . 272, No. 39, 1997, pp. 24319-24. doi : 10.1074 / jbc.272.39.24319 . PMID 9305888 .
  • Takahashi S, Takahashi K, Kaneko T, et al. : Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase . In: J. Biochem. . 125, No. 2, 1999, pp. 348-53. doi : 10.1093 / oxfordjournals.jbchem.a022293 . PMID 9990133 .
  • Takahashi S, Kumagai M, Shindo S, et al. : Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein) . In: J. Biochem. . 128, No. 6, 2001, pp. 951-6. doi : 10.1093 / oxfordjournals.jbchem.a022846 . PMID 11098137 .
  • Simpson JC, Wellenreuther R, Poustka A, et al. : Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . In: EMBO Rep. . 1, No. 3, 2001, pp. 287-92. doi : 10.1093 / embo-reports / kvd058 . PMID 11256614 . PMC 1083732 (free full text).
  • Lapteva N, Nieda M, Ando Y, et al. : Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray . In: Biochem Biophys Res Commun . 285, No. 4, 2001, pp. 1059-65. doi : 10.1006 / bbrc.2001.5215 . PMID 11467860 .
  • Takahashi S, Ogasawara H, Takahashi K, et al. : Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein) . In: J. Biochem . 131, No. 4, 2002, pp. 605-10. doi : 10.1093 / oxfordjournals.jbchem.a003140 . PMID 11926999 .
  • Strausberg RL, Feingold EA, Grouse LH, et al. : Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . In: Proc Natl Acad Sci USA . 99, No. 26, 2003, pp. 16899-903. doi : 10.1073 / pnas.242603899 . PMID 12477932 . PMC 139241 (free full text).
  • Luchansky SJ, Yarema KJ, Takahashi S, Bertozzi CR: GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism . In: J. Biol. Chem . 278, No. 10, 2003, pp. 8035-42. doi : 10.1074 / jbc.M212127200 . PMID 12499362 .
  • Bohlmeyer T, Ferdensi A, Bristow MR, et al. : Selective activation of N-acyl-D-glucosamine 2-epimerase expression in failing human heart ventricular myocytes . In: J. Card. Fail . 9, No. 1, 2003, pp. 59-68. doi : 10.1054 / jcaf.2003.6 . PMID 12612874 .
  • Gerhard DS, Wagner L, Feingold EA, et al. : The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . In: Genome Res . 14, No. 10B, 2004, pp. 2121-7. doi : 10.1101 / gr.2596504 . PMID 15489334 . PMC 528928 (free full text).
  • Rual JF, Venkatesan K, Hao T, et al. : Towards a proteome-scale map of the human protein-protein interaction network . In: Nature . 437, No. 7062, 2005, pp. 1173-8. doi : 10.1038 / nature04209 . PMID 16189514 .