N -cyclohexyl- N '- (2-morpholinoethyl) carbodiimide-methyl- p -toluenesulfonate

Structural formula
General
Surname	N -cyclohexyl- N '- (2-morpholinoethyl) carbodiimide-methyl- p -toluenesulfonate
other names	4- {2 - [(Cyclohexylcarbonimidoyl) amino] ethyl} -4-methylmorpholinium p -toluenesulfonate N -cyclohexyl- N '- [β- ( N -methylmorpholino) ethyl] carbodiimide- p -toluenesulfonate N- cyclohexyl- N '- (2-morpholinoethyl) carbodiimide metho- p -toluenesulfonate CMC metho- p -toluene sulfonate CMC MorphoCDI
Molecular formula	C 14 H 26 N 3 O • C 7 H 7 O 3 S
External identifiers / databases
CAS number 2491-17-0 EC number 219-650-3 ECHA InfoCard 100.017.865 Wikidata Q27902941
properties
Molar mass	423.57 g mol −1
Physical state	firmly
Melting point	113-115 ° C
safety instructions
GHS labeling of hazardous substances no GHS pictograms H and P phrases H: no H-phrases P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

N -Cyclohexyl- N '- (2-morpholinoethyl) carbodiimide-methyl- p -toluenesulfonate is a coupling reagent from the group of carbodiimides . It is used in peptide synthesis . It was developed in 1956 by John Sheehan and Joseph Hlavka.

Individual evidence

1. ↑ ^{a b} Data sheet N-Cyclohexyl-N ′ - (2-morpholinoethyl) carbodiimide methyl-p-toluenesulfonate, 95% from Sigma-Aldrich , accessed on October 22, 2016 ( PDF ).
2. ↑ Horst Kunz, Regina Barthels: The 2- (2-pyridyl) ethoxycarbonyl (Pyoc) residue - an acid- and base-stable, hydrophilic protective group for the amino function in peptide synthesis. In: Angewandte Chemie . 95, 1983, p. 799, doi : 10.1002 / anie.19830951011 .
3. ^ JC Sheehan, JJ Hlavka: Water soluble carbodiimide. In: J. Org. Chem. (1956), Vol. 21, p. 439.