Neuroglobin
| Neuroglobin | ||
|---|---|---|
|
||
| Ribbon model of mouse neuroglobin with heme as rods according to PDB 1Q1F | ||
| Properties of human protein | ||
| Mass / length primary structure | 151 amino acids | |
| Secondary to quaternary structure | Monomer | |
| Cofactor | Hamm | |
| Identifier | ||
| Gene name | NGB | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Vertebrates | |
Neuroglobin is an oxygen-transporting protein , similar to hemoglobin , found in vertebrates . In humans, it is involved in the transport of oxygen in the brain. It is mainly expressed in the frontal lobe , subthalamic nucleus, and thalamus . It belongs to the globins .
The mouse-specific and human neuroglobin genes were characterized in 2000. In humans, the neuroglobin gene is on chromosome 14q21 . Neuroglobin is related to human globins, but has a peculiar gene structure. Sequence analyzes showed that it forms its own family of proteins and formed early in the evolution of multicellular animals (metazoa) - before the separation of the original mouths (protostomia) from the new mouths (deuterostomia).
See also
swell
Review articles
- Pesce A. et al .: Neuroglobin and Cytoglobin: Fresh blood for the vertebrate globin family. EMBO Rep. 2002, (12), 1146-1151. PMID 12475928
- Burmester, T. et al .: Neuroglobin: a respiratory protein of the nervous system. News Physiol. Science 2004, (19), 110-113. PMID 15143204
- Burmester, T. et al .: Neuroglobin and Cytoglobin: Genes, Proteins and Evolution IUBMB Life. 2004, 11-12, 703-307 PMID 15804835
- Fago, A. et al .: Functional properties of neuroglobin and cytoglobin. Insights into the functional anchestral roles of globins. IUBMB Life. 2004, 11-12, 689-696. PMID 15804833
- Fordel, E. et al .: Hypoxia / ischaemia and the regulation of neuroglobin and cytoglobin expression IUBMB Life. 2004, 11-12, 681-687. PMID 15804832
- Hankeln, T. et al .: The cellular and subcellular localization of neuroglobin and cytoglobin. A clue to their function? IUBMB Life. 2004, 11-12, 671-679. PMID 15804831
- Hankeln T. et al .: Neuroglobin and Cytoglobin in search of their role in vertebrate globin family. J Inorg. Biochem. 2005, (1), 110-119. PMID 15598495