Cytoglobin
| Cytoglobin | ||
|---|---|---|
|
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| Ribbon model of the dimer, with heme as rods, according to PDB 1UMO | ||
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Existing structural data: s. UniProt |
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| Properties of human protein | ||
| Mass / length primary structure | 190 amino acids | |
| Secondary to quaternary structure | Homodimer | |
| Cofactor | Hamm | |
| Identifier | ||
| Gene name | CYGB | |
| External IDs | ||
Cytoglobin is a member of the globin family . This also includes the muscle protein myoglobin , the blood protein hemoglobin , and the neuroglobin in the nervous system.
The cytoglobin , which was first described in 2002, occurs in almost all cells of vertebrates . It is believed to be used to transport and store oxygen in the cell , as well as to protect against oxidative stress . It even appears that cytoglobin has evolved into the muscle-specific variant myoglobin through gene duplication .
The cytoglobin gene was characterized in 2002 in humans, mice and zebrafish . The human cytoglobin gene is located on chromosome 17q25 . In humans and mice the protein is 190 amino acids (AA) in size, in zebrafish 174 AA. Cytoglobin is expressed in all tissues in humans and, according to sequence analyzes, has a common evolutionary precursor with myoglobin.
See also
swell
Review articles
- Pesce A. et al .: Neuroglobin and Cytoglobin: Fresh blood for the vertebrate globin family. EMBO Rep. 2002, (12), 1146-1151. PMID 12475928
- Burmester, T. et al .: Neuroglobin: a respiratory protein of the nervous system. News Physiol. Science 2004, (19), 110-113. PMID 15143204
- Burmester, T. et al .: Neuroglobin and Cytoglobin: Genes, Proteins and Evolution IUBMB Life. 2004, 11-12, 703-307 PMID 15804835
- Fago, A. et al .: Functional properties of neuroglobin and cytoglobin. Insights into the functional anchestral roles of globins. IUBMB Life. 2004, 11-12, 689-696. PMID 15804833
- Fordel, E. et al .: Hypoxia / ischaemia and the regulation of neuroglobin and cytoglobin expression IUBMB Life. 2004, 11-12, 681-687. PMID 15804832
- Hankeln, T. et al .: The cellular and subcellular localization of neuroglobin and cytoglobin. A clue to their function? IUBMB Life. 2004, 11-12, 671-679. PMID 15804831
- Hankeln T. et al .: Neuroglobin and Cytoglobin in search of their role in vertebrate globin family. J Inorg. Biochem. 2005, (1), 110-119. PMID 15598495
Technical article
- Burmester, T. et al .: A vertebrate globin expressed in the brain. Nature 2000, 407 (6803) 461-462. PMID 11029004
- Burmester, T. et al .: Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues. Molecular Biology and Evolution 19: 416-421 (2002) PMID 11919282
- Fuchs, C. et al .: Duplicated cytoglobin genes in teleost fishes. Biochem Biophys Res Commun 2005, 337 (1) 216-23. PMID 16199220
- de Sanctis, D. et al .: Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination. J Mol Biol. 2004 336 (4), 917-927. PMID 15095869
- Schmidt, M .: Neuroscience Letters 2005, (3), 207-211. PMID 15663964