Nisoxetine

Structural formula
	1: 1 mixture (racemate) of the ( R ) form (left) and the ( S ) form (right)
General
Non-proprietary name	Nisoxetine
other names	( RS ) -3- (2-methoxyphenoxy) - N -methyl-3-phenylpropylamine ( IUPAC ) ; (±) -3- (2-Methoxyphenoxy) - N -methyl-3-phenylpropylamine; Nisoxetinum ( Latin ) ; Compound 89218 (Lilly, USA);
Molecular formula	C 17 H 21 NO 2
Brief description	colorless solid (hydrochloride)
External identifiers / databases
PubChem	4500
ChemSpider	4344
DrugBank	DB09186
Wikidata	Q906885
Drug information
Drug class	Antidepressants
Mechanism of action	Selective norepinephrine reuptake inhibitor
properties
Molar mass	271.35 g · mol -1
Physical state	firmly
pK s value	10.162
solubility	20 mg / ml in water (hydrochloride); 50 mg / ml in ethanol (hydrochloride);
safety instructions
GHS labeling of hazardous substances Hydrochloride;	no GHS pictograms
	no GHS pictograms
H and P phrases	H: no H-phrases
	P: no P-phrases
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Nisoxetine ( LY-94939 ) is a selective norepinephrine reuptake inhibitor (NARI).

It was originally developed as an antidepressant but did not get beyond the development stage. However, it is considered the “standard NARI” in scientific research and is often used as such. It is used as a racemate .

Individual evidence

↑ ^a ^b ^c ^d data sheet Nisoxetine hydrochloride from Sigma-Aldrich , accessed on April 16, 2011 ( PDF ).
↑ Nisoxetine, Compound ID CHEMBL295467 in the ChEMBL database.
↑ S. Kelwala, M. Stanley, S. Gershon: History of antidepressants: successes and failures. In: Journal of Clinical Psychiatry. 44 (5 Pt 2), May 1983, pp. 40-48. PMID 6222036 .
^ D. Graham, SZ Langer: Advances in sodium-ion coupled biogenic amine transporters. In: Life Sciences . 51 (9), 1992, pp. 631-645. PMID 1501510 .

[Sigma-1] ta sheet Nisoxetine hydrochloride from Sigma-Aldrich , accessed on April 16, 2011 ( PDF ).

[2] Nisoxetine, Compound ID CHEMBL295467 in the ChEMBL database.

[3] S. Kelwala, M. Stanley, S. Gershon: History of antidepressants: successes and failures. In: Journal of Clinical Psychiatry. 44 (5 Pt 2), May 1983, pp. 40-48. PMID 6222036 .

[4] D. Graham, SZ Langer: Advances in sodium-ion coupled biogenic amine transporters. In: Life Sciences . 51 (9), 1992, pp. 631-645. PMID 1501510 .