Osateron
| Structural formula | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|||||||||||||
| General | |||||||||||||
| Non-proprietary name | Osateron | ||||||||||||
| other names |
(+) - 6-chloro-17-hydroxy-2-oxapregna-4,6-diene-3,20-dione |
||||||||||||
| Molecular formula | C 20 H 25 ClO 4 | ||||||||||||
| External identifiers / databases | |||||||||||||
|
|||||||||||||
| Drug information | |||||||||||||
| ATC code | |||||||||||||
| Drug class | |||||||||||||
| Mechanism of action |
Inhibition of testosterone uptake in the prostate cells |
||||||||||||
| properties | |||||||||||||
| Molar mass | 364.9 g mol −1 | ||||||||||||
| solubility |
almost insoluble in water, freely soluble in chloroform and tetrahydrofuran |
||||||||||||
| safety instructions | |||||||||||||
|
|||||||||||||
| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | |||||||||||||
Osaterone is a synthetic antiandrogen that is chemically related to chlormadinone . It is used in veterinary medicine as an ester of acetic acid (osaterone acetate, trade name Ypozane ) for the treatment of benign prostatic hyperplasia . It inhibits testosterone uptake in the prostate cells, while the serum level of testosterone is practically unaffected.
The active ingredient is well absorbed after ingestion. The plasma protein binding is 87-92% in the dog. Osaterone is metabolized in the liver and excreted in the bile, feces and urine. The elimination half-life is about 80 hours.
Osateron is well tolerated. An increase in appetite and changes in personality can occur as side effects. Since the active ingredient also, albeit low affinity to the glucocorticoid - receptors has, there may be a slight drop in cortisol come in the serum, but not manifested clinically. The administration of the active ingredient should therefore only be given if the adrenal gland is underactive, and it can influence the results of an ACTH stimulation test.